Evidence map›Paper›PMID 32723007›Full record

ArticleEmerging microbes & infections2020

Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus.

Anges Yadouleton, Caroline Picard, Toni Rieger, Frederic Loko, Daniel Cadar, Emile Cossi Kouthon, Emmanuel Obolli Job, Honoré Bankolé, Lisa Oestereich, Fernand Gbaguidi and 17 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  13. Robust polyfunctional CD8The Journal of general virology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Anges YadouletonLaboratoire des Fièvres Hémorragiques Virales, Cotonou, Benin.
Caroline PicardVirology Department, Institut Pasteur CNR des fièvres hémorragiques virales (CNR FHV), Lyon, France.
Toni RiegerVirology Department, Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany.
Frederic LokoMinistry of Health, Cotonou, Benin.
Daniel CadarVirology Department, Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany.
Emile Cossi KouthonHospital St Martin de Papané, Papané, Benin.
Emmanuel Obolli JobSanitary Coordination, Tchaourou, Benin.
Honoré BankoléMinistry of Health, Cotonou, Benin.
Lisa OestereichVirology Department, Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany.
Fernand GbaguidiUniversity of Abomey-Calavi, Cotonou, Benin.
Meike PahlmanVirology Department, Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany.
Beate Becker-ZiajaVirology Department, Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany.
Alexandra JourneauxLaboratoire des Fièvres Hémorragiques Virales, Cotonou, Benin.
Delphine PannetierINSERM - Jean Mérieux BSL4Laboratory, CNR FHV, Lyon, France.
Stéphane MélyINSERM - Jean Mérieux BSL4Laboratory, CNR FHV, Lyon, France.ORCID https://orcid.org/0000-0002-3278-3455
Stéphanie MundweilerINSERM - Jean Mérieux BSL4Laboratory, CNR FHV, Lyon, France.
Damien ThomasINSERM - Jean Mérieux BSL4Laboratory, CNR FHV, Lyon, France.
Leon KohossiWorld Health Organization, Cotonou, Benin.
Raoul SaizonouWorld Health Organization, Cotonou, Benin.
Clement Glele KakaïWorld Health Organization, Cotonou, Benin.
Magloire Da SilvaMinistry of Health, Cotonou, Benin.
Sonia KossoubedieWorld Health Organization, Cotonou, Benin.
André Lukusa KakonkuWorld Health Organization, Cotonou, Benin.
Pierre M'PeléWorld Health Organization, Cotonou, Benin.
Stephan GuntherVirology Department, Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany.
Sylvain BaizeLaboratoire des Fièvres Hémorragiques Virales, Cotonou, Benin.
Elisabeth Fichet-CalvetVirology Department, Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID https://orcid.org/0000-0002-9421-3538

Funding

World Health Organization 001
6 · The paper itself

Abstract

We report two outbreaks of Lassa fever that occurred in Benin in 2014 and 2016 with 20 confirmed cases and 50% (10/20) mortality. Benin was not previously considered to be an endemic country for Lassa fever, resulting in a delay to diagnose the disease and its human transmission. Molecular investigations showed the viral genomes to be similar to that of the Togo strain, which is genetically very different from other known strains and confirms the existence of a new lineage. Endemic circulation of Lassa virus in a new territory and the genetic diversity thus confirm that this virus represents a growing threat for West African people. Given the divergence of the Benin strain from the prototypic Josiah Sierra Leone strain frequently used to generate vaccine candidates, the efficacy of vaccine candidates should also be demonstrated with this strain.

Indexed as

AdultAntibodies, ViralBeninDisease OutbreaksFemaleGenome, ViralHumansImmunoglobulin GImmunoglobulin MLassa FeverLassa virusMalePhylogenyRNA, ViralAntibodies, ViralImmunoglobulin GImmunoglobulin MRNA, ViralBeningenomeLassa feverLassa virusnew lineageoutbreakphylogenyserology

Identifiers

PMID32723007
PMCPMC7473144

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.