Evidence map›Paper›PMID 32723003›Full record

ArticleStem cells and development2020

The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.

Xiaomeng Hu, Simon T Kueppers, Nigel G Kooreman, Alessia Gravina, Dong Wang, Grigol Tediashvili, Stephan Schlickeiser, Marco Frentsch, Christos Nikolaou, Andreas Thiel and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells and development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Xiaomeng HuTransplant and Stem Cell Immunobiology Lab, Department of Surgery, University of California, San Francisco, California, USA.
Simon T KueppersTransplant and Stem Cell Immunobiology Lab, Department of Surgery, University of California, San Francisco, California, USA.
Nigel G KooremanStanford Cardiovascular Institute, Stanford University, Stanford, California, USA.
Alessia GravinaTransplant and Stem Cell Immunobiology Lab, Department of Surgery, University of California, San Francisco, California, USA.
Dong WangTransplant and Stem Cell Immunobiology Lab, Department of Surgery, University of California, San Francisco, California, USA.
Grigol TediashviliTransplant and Stem Cell Immunobiology Lab, Department of Surgery, University of California, San Francisco, California, USA.
Stephan SchlickeiserBIH-Center for Regenerative Therapies (BCRT), Charité University Medicine and Berlin Institute of Health (BIH), Berlin, Germany.
Marco FrentschBIH-Center for Regenerative Therapies (BCRT), Charité University Medicine and Berlin Institute of Health (BIH), Berlin, Germany.
Christos NikolaouBIH-Center for Regenerative Therapies (BCRT), Charité University Medicine and Berlin Institute of Health (BIH), Berlin, Germany.
Andreas ThielBIH-Center for Regenerative Therapies (BCRT), Charité University Medicine and Berlin Institute of Health (BIH), Berlin, Germany.
Sivan MarcusTransplant and Stem Cell Immunobiology Lab, Department of Surgery, University of California, San Francisco, California, USA.
Sigrid FuchsInstitute of Human Genetics, University Medical Center Hamburg, Hamburg, Germany.
Joachim VeldenEvotec AG, Histopathology and In Vivo Pharmacology, Hamburg, Germany.
Hermann ReichenspurnerCardiovascular Research Center Hamburg (CVRC) and DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Luebeck, Hamburg, Germany.
Hans-Dieter VolkBIH-Center for Regenerative Therapies (BCRT), Charité University Medicine and Berlin Institute of Health (BIH), Berlin, Germany.
Tobias DeuseTransplant and Stem Cell Immunobiology Lab, Department of Surgery, University of California, San Francisco, California, USA.
Sonja SchrepferTransplant and Stem Cell Immunobiology Lab, Department of Surgery, University of California, San Francisco, California, USA.
Charité - Universitätsmedizin Berlin · DEHumboldt-Universität zu Berlin · DELeiden University Medical Center · NLUniversity Medical Center Hamburg-Eppendorf · DE

Funding

Hypo-immunogenic cardiomyocytes for myocardial repairR01HL140236 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEUSE, TOBIAS, LANIER, LEWIS LEE · 2018 to 2021
$3.1M
NHLBI NIH HHS R01 HL140236
6 · The paper itself

Abstract

Pluripotent stem cells are promising candidates for cell-based regenerative therapies. To avoid rejection of transplanted cells, several approaches are being pursued to reduce immunogenicity of the cells or modulate the recipient's immune response. These include gene editing to reduce the antigenicity of cell products, immunosuppression of the host, or using major histocompatibility complex-matched cells from cell banks. In this context, we have investigated the antigenicity of H-Y antigens, a class of minor histocompatibility antigens encoded by the Y chromosome, to assess whether the gender of the donor affects the cell's antigenicity. In a murine transplant model, we show that the H-Y antigen in undifferentiated embryonic stem cells (ESCs), as well as ESC-derived endothelial cells, provokes T- and B cell responses in female recipients.

Indexed as

AnimalsAnimals, NewbornB-LymphocytesEmbryonic Stem CellsFemaleGraft RejectionH-Y AntigenImmune ToleranceImmunityMaleMiceMice, Inbred BALB CStem Cell TransplantationSurvival AnalysisT-LymphocytesH-Y Antigenallograftimmunogenicitypluripotent stem cellsstem cell therapeuticsY-chromosome

Identifiers

PMID32723003
PMCPMC7482111
OpenAlexW3045722706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.