ReviewThe Journal of international medical research2020
Endothelial activation and dysfunction in metabolic syndrome, type 2 diabetes and coronavirus disease 2019.
Review in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 68 citations in OpenAlex.
- Pequi (Antioxidants (Basel, Switzerland) · 2025Article
- miR-92a aggravates metabolic syndrome via KLF2/miR-483 axis.Journal of diabetes investigation · 2025Article
- Assessing the impact of comorbidities on disease severity in COVID-19 patients requires consideration of age.Medicine · 2025Observational
- Clinical characteristics of adult asthma patients hospitalized by COVID-19 in Mexico City: a real-world study.Annals of medicine · 2024Observational
- COVID-19 is associated with high blood glucose levels: diabetic neuropathy during the SARS-CoV-2 pandemic: a case report.Annals of medicine and surgery (2012) · 2024Article
- Brain endothelial cell activation and dysfunction associate with and contribute to the development of enlarged perivascular spaces and cerebral small vessel disease.Histology and histopathology · 2024Review
- Clinical Characteristics of Hospitalized Patients With COVID-19 and Their Association With the Progression to Critical Illness and Death: A Single-Center Retrospective Study From Northwestern Mexico.The clinical respiratory journal · 2024Article
- Diabetes related phenotypes and their influence on outcomes of patients with corona virus disease 2019 (COVID-19).Diabetology & metabolic syndrome · 2023Article
- Brain Injury: Response to Injury Wound-Healing Mechanisms and Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2023Review
- Why Are Perivascular Spaces Important?Medicina (Kaunas, Lithuania) · 2023Review
- Review
- Therapeutic role of growth factors in treating diabetic wound.World journal of diabetes · 2023Review
- Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance.Journal of inflammation (London, England) · 2023Review
- Overview and New Insights into the Metabolic Syndrome: Risk Factors and Emerging Variables in the Development of Type 2 Diabetes and Cerebrocardiovascular Disease.Medicina (Kaunas, Lithuania) · 2023Review
- Ultrastructural Remodeling of the Blood-Brain Barrier and Neurovascular Unit by Lipopolysaccharide-Induced Neuroinflammation.International journal of molecular sciences · 2023Article
- High levels of exfoliated fragments following glycocalyx destruction in hemorrhagic fever with the renal syndrome are associated with mortality risk.Frontiers in medicine · 2023Article
- Examining the Determinants of COVID-19 Severity: A Cohort Study in Morocco of 915 Patients.Cureus · 2022Article
- Insulin use in type II diabetic patients: a predictive of mortality in covid-19 infection.Diabetology & metabolic syndrome · 2022Article
- The Mighty Mitochondria Are Unifying Organelles and Metabolic Hubs in Multiple Organs of Obesity, Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes: An Observational Ultrastructure Study.International journal of molecular sciences · 2022Review
- Endothelial cells and blood vessels are major targets for COVID-19-induced tissue injury and spreading to various organs.World journal of gastroenterology · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 infection is a serious global concern. Increased morbidity and mortality is associated with older age, male gender, cardiovascular disease, diabetes, and smoking. As COVID-19 spreads from coastal borders, both state to state and country to country, our understanding of its pathophysiology has evolved. Age and type 2 diabetes mellitus (T2DM) play especially important roles in COVID-19 progression. T2DM is an age-related disease associated with metabolic syndrome, obesity, insulin resistance (hyperinsulinemia), hyperlipidemia, hypertension, hyperglycemia, and endothelial activation and dysfunction. This review evaluates the relationships and intersection between endothelial cell activation and dysfunction in T2DM and COVID-19. COVID-19 induces multiple injuries of the terminal bronchioles and alveolar blood-gas barrier and associated ultrastructural tissue remodeling. COVID-19 may unmask multiple vulnerabilities associated with T2DM including damage to the endothelial glycocalyx and multiple end-organ macro and microvascular diseases. Unmasking existing vulnerabilities in diabetic patients with COVID-19 is important. Globally, we must come together to better understand why T2DM is associated with increased COVID-19 morbidity and mortality.
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