Evidence map›Paper›PMID 32722523›Full record

ArticleViruses2020

Yellow Fever Virus Down-Regulates mRNA Expression of SOCS1 in the Initial Phase of Infection in Human Cell Lines.

Michael B Yakass, David Franco, Osbourne Quaye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Michael B YakassWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon-Accra 00233, Ghana.ORCID 0000-0002-6903-0633
David FrancoGSK Vaccines, 1330 Rixensart, Belgium.
Osbourne QuayeWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon-Accra 00233, Ghana.ORCID 0000-0002-0621-876X
University of Ghana · GHGlaxoSmithKline (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flaviviruses are constantly evolving diverse immune evasion strategies, and the exploitation of the functions of suppressors of cytokine signalling (SOCS) and protein inhibitors of activated STATs (PIAS) to favour virus replication has been described for Dengue and Japanese encephalitis viruses but not for yellow fever virus (YFV), which is still of global importance despite the existence of an effective vaccine. Some mechanisms that YFV employs to evade host immune defence has been reported, but the expression patterns of

Indexed as

Down-RegulationHEK293 CellsHeLa CellsHumansProtein Inhibitors of Activated STATSuppressor of Cytokine Signaling 1 ProteinVirus ReplicationYellow fever virusProtein Inhibitors of Activated STATSOCS1 protein, humanSuppressor of Cytokine Signaling 1 Proteinflavivirusprotein inhibitors of activated STATs (PIAS)suppressors of cytokine signalling (SOCS)yellow fever virus

Identifiers

PMID32722523
PMCPMC7472022
OpenAlexW3044718543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.