Evidence map›Paper›PMID 32722255›Full record

ArticleMolecules (Basel, Switzerland)2020

Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics.

Nolan M Dvorak, Paul A Wadsworth, Pingyuan Wang, Haiying Chen, Jia Zhou, Fernanda Laezza

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Inhibition of the GSK3β/Nav1.6 complex suppresses early-stage Alzheimer's hyperexcitability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
  5. Article
  6. Voltage-Gated NaLife (Basel, Switzerland) · 2023
    Review
  7. Inhibition of the Akt/PKB Kinase Increases NaInternational journal of molecular sciences · 2022
    Article
  8. Article
  9. Article
  10. Differential Modulation of the Voltage-Gated NaFrontiers in molecular biosciences · 2021
    Article
  11. Development of Allosteric Modulators of Voltage-Gated NaCurrent topics in medicinal chemistry · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nolan M DvorakDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.ORCID 0000-0003-1280-9918
Paul A WadsworthDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.ORCID 0000-0002-4562-7830
Pingyuan WangDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
Haiying ChenDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.ORCID 0000-0003-2841-5518
Jia ZhouDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.ORCID 0000-0002-2811-1090
Fernanda LaezzaDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
The University of Texas Medical Branch at Galveston · US

Funding

HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0M
Neurotrophin-dependent regulation of voltage-gated sodium channelsR01MH124351 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2020 to 2024
$3.0M
Validation of FGF14 as a New Molecular Target of GSK3R01MH095995 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2012 to 2016
$1.9M
Discovery of Chemical Probes for Psychiatric Disorders and AddictionR01MH111107 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA, ZHOU, JIA · 2016 to 2018
$1.6M
Core Center for Translational Addiction SciencesP30DA028821 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 2009 to 2010
$1.5M
Clinical and Behavioral Science Training in Aging and Health DisparitiesT32AG051131 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARKIDES, KYRIAKOS S · 2015 to 2019
$436k
FGF13: a novel druggable target for treating substance abuse disordersU18DA052504 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2020 to 2020
$237k
Malvern MicroCal PEAQ Isothermal Titration CalorimeterS10OD023576 · OD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RAJARATHNAM, KRISHNA · 2017 to 2017
$120k
NIA NIH HHS T32AG051131NIDA NIH HHS U18 DA052504NIGMS NIH HHS T32 GM008280NIH HHS P30DA028821NIH HHS R01MH095995NIH HHS R01MH111107NIH HHS R01MH124351NIH HHS S10 OD023576NIH HHS S10OD023576NIMH NIH HHS R01 MH111107NIMH NIH HHS R01 MH124351
6 · The paper itself

Abstract

Disruption of protein:protein interactions (PPIs) that regulate the function of voltage-gated Na

Indexed as

Allosteric RegulationBinding SitesDrug DesignFibroblast Growth FactorsHEK293 CellsHumansHydrophobic and Hydrophilic InteractionsModels, MolecularMolecular Docking SimulationMolecular StructureNAV1.6 Voltage-Gated Sodium ChannelPeptidomimeticsProtein BindingProtein Structure, Secondaryfibroblast growth factor 14Fibroblast Growth FactorsNAV1.6 Voltage-Gated Sodium ChannelPeptidomimeticsSCN8A protein, humanfibroblast growth factor 14 (FGF14)molecular dockingneurotherapeuticspeptidomimeticsprotein:protein interactions (PPIs)voltage-gated Na+ (Nav) channels

Identifiers

PMID32722255
PMCPMC7435778
OpenAlexW3045251346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.