ArticleAntioxidants (Basel, Switzerland)2020
Flavonoids Identification and Pancreatic Beta-Cell Protective Effect of Lotus Seedpod.
Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Dietary Quercetin-3-Glucuronide Mitigates Oxidative Stress, Inflammation, and Fibroblast Transition by Regulating Nrf2 and Autophagy in Pulmonary Fibrosis.Journal of agricultural and food chemistry · 2026Article
- An Insight on Flavonoids and Flavonoidsincorporated Nano-formulations in the Management of Diabetes Mellitus.Current diabetes reviews · 2026Review
- Protective Effects of Lotus Seedpod Extract on Hepatic Lipid and Glucose Metabolism via AMPK-Associated Mechanisms in a Mouse Model of Metabolic Syndrome and Oleic Acid-Induced HepG2 Cells.Antioxidants (Basel, Switzerland) · 2025Article
- Hypoglycemic effects of Caesalpinia bonduc (L). Roxb leaf extract in streptozotocin-induced diabetic rats.Pediatric endocrinology, diabetes, and metabolism · 2025Article
- Structural characterization and protective effects of polysaccharides isolated fromFrontiers in nutrition · 2025Article
- Metformin enhances METTL14-Mediated m6A methylation to alleviate NIT-1 cells apoptosis induced by hydrogen peroxide.Heliyon · 2024Article
- Component Characterization, In Vitro Activities and Molecular Mechanism ofPharmaceuticals (Basel, Switzerland) · 2022Article
- In Vitro and In Vivo Nephroprotective Effects ofPlants (Basel, Switzerland) · 2022Article
- Antioxidant Effect of Tyr-Ala Extracted from Zein on INS-1 Cells and Type 2 Diabetes High-Fat-Diet-Induced Mice.Antioxidants (Basel, Switzerland) · 2022Article
- Phytochemicals, biological activity, and industrial application of lotus seedpod (Frontiers in nutrition · 2022Review
- Anti-Atherosclerotic Effect of Gossypetin on Abnormal Vascular Smooth Muscle Cell Proliferation and Migration.Antioxidants (Basel, Switzerland) · 2021Article
- New Mechanisms of Action of Natural Antioxidants in Health and Disease II.Antioxidants (Basel, Switzerland) · 2021Article
- Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects.Antioxidants (Basel, Switzerland) · 2021Review
- Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials.Antioxidants (Basel, Switzerland) · 2020Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Oxidative stress is highly associated with the development of diabetes mellitus (DM), especially pancreatic beta-cell injury. Flavonoids derived from plants have caused important attention in the prevention or treatment of DM. Lotus seedpod belongs to a traditional Chinese herbal medicine and has been indicated to possess antioxidant, anti-age, anti-glycative, and hepatoprotective activities. The purpose of this study was to demonstrate the pancreatic beta-cell protective effects of lotus seedpod aqueous extracts (LSE) against oxidative injury. According to HPLC/ESI-MS-MS method, LSE was confirmed to have flavonoids derivatives, especially quercetin-3-glucuronide (Q3G). In vitro, LSE dose-dependently improved the survival and function of rat pancreatic beta-cells (RIN-m5F) from hydrogen peroxide (H
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