Evidence map›Paper›PMID 32722086›Full record

ArticleMolecules (Basel, Switzerland)2020

Design, Synthesis and Bioactive Evaluation of Oxime Derivatives of Dehydrocholic Acid as Anti-Hepatitis B Virus Agents.

Zhuocai Wei, Jie Tan, Xinhua Cui, Min Zhou, Yunhou Huang, Ning Zang, Zhaoni Chen, Wanxing Wei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhuocai WeiCollege of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
Jie TanCollege of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
Xinhua CuiCollege of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
Min ZhouCollege of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
Yunhou HuangCollege of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
Ning ZangSchool of Basic Medical Science, Guangxi Medical University, Nanning 530021, China.
Zhaoni ChenPharmaceutical College, Guangxi Medical University, Nanning 530021, China.
Wanxing WeiCollege of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.ORCID 0000-0002-6457-6784
Guangxi University · CNGuangxi Medical University · CN

Funding

the National natural science foundation of China 81760635
6 · The paper itself

Abstract

Oxime derivatives of dehydrocholic acid and its esters were designed for anti-hepatitis B virus (HBV) drugs according to principles of assembling active chemical fragments. Twelve compounds were synthesized from dehydrocholic acid by esterification and oxime formation, and their anti-hepatitis B virus (HBV) activities were evaluated with HepG 2.2.15 cells. Results showed that 5 compounds exhibited more effective inhibition of HBeAg than positive control, among them

Indexed as

Antiviral AgentsDehydrocholic AcidEsterificationGuanineHeparan Sulfate ProteoglycansHepatitis B e AntigensHepatitis B virusHep G2 CellsHumansMolecular Docking SimulationMolecular StructureOximesReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearAntiviral AgentsDehydrocholic AcidentecavirGuanineHeparan Sulfate ProteoglycansHepatitis B e AntigensOximesReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclearanti-HBVdehydrocholic aciddesignationoxime derivativessynthesis

Identifiers

PMID32722086
PMCPMC7435646
OpenAlexW3044595855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.