Evidence map›Paper›PMID 32721974›Full record

ArticleNeuroendocrinology2021

Reliability and Agreement of Radiological and Pathological Tumor Size in Patients with Multiple Endocrine Neoplasia Type 1-Related Pancreatic Neuroendocrine Tumors: Results from a Population-Based Cohort.

Dirk-Jan van Beek, Helena M Verkooijen, Sjoerd Nell, Bert A Bonsing, Casper H van Eijck, Harry van Goor, Frederik J H Hoogwater, Elisabeth J M Nieveen van Dijkum, Geert Kazemier, Cornelis H C Dejong and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dirk-Jan van BeekDepartment of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Helena M VerkooijenImaging Division, University Medical Center Utrecht, Utrecht, The Netherlands.
Sjoerd NellDepartment of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Bert A BonsingDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Casper H van EijckDepartment of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
Harry van GoorDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Frederik J H HoogwaterDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Elisabeth J M Nieveen van DijkumDepartment of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Center location Academic Medical Center, Amsterdam, The Netherlands.
Geert KazemierDepartment of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Center location VUmc University Medical Center, Amsterdam, The Netherlands.
Cornelis H C DejongDepartment of Surgery, Maastricht University Medical Center, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands.
Lodewijk A A BrosensDepartment of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Frank J WesselsDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Inne H M Borel RinkesDepartment of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Gerlof D ValkDepartment of Endocrine Oncology, University Medical Center, Utrecht, The Netherlands.
Menno R VriensDepartment of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands, mvriens@umcutrecht.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic neuroendocrine tumors (pNETs) have a high prevalence in patients with multiple endocrine neoplasia type 1 (MEN1) and are the leading cause of death. Tumor size is still regarded as the main prognostic factor and therefore used for surgical decision-making. We assessed reliability and agreement of radiological and pathological tumor size in a population-based cohort of patients with MEN1-related pNETs.

methodsPatients were selected from the Dutch MEN1 database if they had undergone a resection for a pNET between 2003 and 2018. Radiological (MRI, CT, and endoscopic ultrasonography [EUS]) and pathological tumor size were collected from patient records. Measures of agreement (Bland-Altman plots with limits of agreement [LoA] and absolute agreement) and reliability (intraclass correlation coefficients [ICC] and unweighted kappa) were calculated for continuous and categorized (< or ≥2 cm) pNET size.

resultsIn 73 included patients, the median radiological and pathological tumor sizes measured were 22 (3-160) and 21 (4-200) mm, respectively. Mean bias between radiological and pathological tumor size was -0.2 mm and LoA ranged from -12.9 to 12.6 mm. For the subgroups of MRI, CT, and EUS, LoA of radiological and pathological tumor size ranged from -9.6 to 10.9, -15.9 to 15.8, and -13.9 to 11.0, respectively. ICCs for the overall cohort, MRI, CT, and EUS were 0.80, 0.86, 0.75, and 0.76, respectively. Based on the 2 cm criterion, agreement was 81.5%; hence, 12 patients (18.5%) were classified differently between imaging and pathology. Absolute agreement and kappa values of MRI, CT, and EUS were 88.6, 85.7, and 75.0%, and 0.77, 0.71, and 0.50, respectively.

conclusionWithin a population-based cohort, MEN1-related pNET size was not systematically over- or underestimated on preoperative imaging. Based on agreement and reliability measures, MRI is the preferred imaging modality.

Indexed as

AdultCohort StudiesDiagnostic ImagingEndosonographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple Endocrine Neoplasia Type 1Pancreatic NeoplasmsReproducibility of ResultsTomography, X-Ray ComputedAgreementComputed tomographyEndoscopic ultrasonographyMagnetic resonance imagingMultiple endocrine neoplasia type 1Pancreatic neuroendocrine tumorReliability

Identifiers

PMID32721974
PMCPMC8491507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.