ArticleNeuroImage. Clinical2020
Common and distinct functional stability abnormalities across three major psychiatric disorders.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- Cortical morphometric gradients reveal molecular and cognitive underpinnings of bipolar disorder.Psychological medicine · 2025Article
- Altered static and dynamic intrinsic brain activity patterns in type 2 diabetic patients.Scientific reports · 2025Article
- Learning evoked centrality dynamics in the schizophrenia brain: entropy, heterogeneity, and inflexibility of brain networks.Journal of psychiatry & neuroscience : JPN · 2025Article
- Personalized temporal interference stimulation targeting striatum reduces functional stability and dynamic connectivity variability in the sensorimotor network.Frontiers in neuroscience · 2025Article
- Abnormal stability of dynamic functional architecture in drug-naïve children with attention-deficit/hyperactivity disorder.BMC psychiatry · 2024Article
- Altered stability of dynamic brain functional architecture in primary open-angle glaucoma: a surface-based resting-state fMRI study.Brain imaging and behavior · 2024Article
- Functional connectivity gradients of the insula to different cerebral systems.Human brain mapping · 2023Article
- Bidirectional connectivity alterations in schizophrenia: a multivariate, machine-learning approach.Frontiers in psychiatry · 2023Article
- Aberrant stability of brain functional architecture in cirrhotic patients with minimal hepatic encephalopathy.Brain imaging and behavior · 2022Article
- Altered stability of brain functional architecture after sleep deprivation: A resting-state functional magnetic resonance imaging study.Frontiers in neuroscience · 2022Article
- Abnormal network homogeneity of default-mode network and its relationships with clinical symptoms in antipsychotic-naïve first-diagnosis schizophrenia.Frontiers in neuroscience · 2022Article
- Altered dynamic spontaneous neural activity in minimal hepatic encephalopathy.Frontiers in neurology · 2022Article
- Shared and distinct functional connectivity of hippocampal subregions in schizophrenia, bipolar disorder, and major depressive disorder.Frontiers in psychiatry · 2022Article
- Alterations in whole-brain dynamic functional stability during memory tasks under dexmedetomidine sedation.Frontiers in neurology · 2022Article
- Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder.Communications biology · 2021Article
- From population to neuron: exploring common mediators for metabolic problems and mental illnesses.Molecular psychiatry · 2021Article
- Abnormal Stability of Dynamic Functional Architecture in Amyotrophic Lateral Sclerosis: A Preliminary Resting-State fMRI Study.Frontiers in neurology · 2021Article
- Altered Functional Connectivity of the Nucleus Accumbens Network Between Deficit and Non-deficit Schizophrenia.Frontiers in psychiatry · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delineating the neuropathological characteristics across psychiatric disorders is critical for understanding their pathophysiology. The purpose of this study was to investigate common and distinct brain functional abnormalities across psychiatric disorders by using functional stability, a recently developed dynamic functional connectivity approach. Resting-state functional magnetic resonance imaging data were collected from a transdisease sample of healthy controls (n = 115) and individuals with schizophrenia (SZ) (n = 47), bipolar disorder (BD) (n = 44), and attention deficit/hyperactivity disorder (ADHD) (n = 40). Functional stability of each voxel was calculated by measuring the concordance of dynamic functional connectivity over time. Differences in functional stability among the four groups were assessed voxel-wisely. Compared to healthy controls, individuals with SZ demonstrated a distributed pattern of higher functional stability in the bilateral inferior temporal gyrus yet lower stability in the bilateral calcarine sulcus and left insula; individuals with BD only manifested local higher stability in the left inferior temporal gyrus; no differences were found between ADHD and healthy individuals. Notably, individuals with SZ and BD had common higher functional stability in the left inferior temporal gyrus, whereas higher functional stability in the right inferior temporal gyrus and lower stability in the bilateral calcarine sulcus and left insula were unique abnormalities in individuals with SZ. Additionally, direct comparisons between disorders revealed that individuals with SZ showed lower functional stability in the right calcarine sulcus compared to those with BD and higher stability in the left inferior temporal gyrus compared to those with ADHD. However, no significant associations between functional stability and clinical symptoms were observed. Our findings suggest that the functional stability approach has the potential to be extended to the domain of psychiatry and encourage further investigations of shared and unique neuropathology of psychiatric disorders.
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