ArticleThe Science of the total environment2020
Exposure to microplastics cause gut damage, locomotor dysfunction, epigenetic silencing, and aggravate cadmium (Cd) toxicity in Drosophila.
Article in The Science of the total environment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 146 citations in OpenAlex.
- Article
- Levels of Trace Metals and Radionuclides in Herbal Materials Obtained from Sales Outlets in Ile-Ife, Southwestern Nigeria.Biological trace element research · 2026Article
- Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models.Advanced healthcare materials · 2026Review
- Integrating microplastics into thermal biology in an insect.Ecotoxicology (London, England) · 2026Article
- Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation.Molecular neurobiology · 2025Review
- Label-Free Identification and Imaging of Microplastic and Nanoplastic Biouptake Using Optical Photothermal Infrared Microspectroscopy.Environmental science & technology · 2025Article
- Multigenerational Effects of Weathered Polyethylene Microplastics onEnvironment & health (Washington, D.C.) · 2025Article
- Chronic chlorothalonil exposure inhibits locomotion and interferes with the gut-liver axis in Pelophylax nigromaculatus tadpoles.Scientific reports · 2025Article
- Microplastic exposure is associated with epigenomic effects in the model organism Pimephales promelas (fathead minnow).The Journal of heredity · 2025Article
- Tuning Biocompatibility and Bactericidal Efficacy as a Function of Doping of Gold in ZnO Nanocrystals.ACS omega · 2024Article
- Impact of Polyethylene Terephthalate Microplastics onBiology · 2024Article
- Biochemical and molecular assessment of oxidative stress in fruit fly exposed to azo dye Brilliant Black PN.Molecular biology reports · 2024Article
- The heart of plastic: utilizing theFrontiers in toxicology · 2024Article
- Serratia marcescens in the intestine of housefly larvae inhibits host growth by interfering with gut microbiota.Parasites & vectors · 2023Article
- Review
- Exposure to polystyrene microplastic beads causes sex-specific toxic effects in the model insect Drosophila melanogaster.Scientific reports · 2023Article
- Aging, longevity, and the role of environmental stressors: a focus on wildfire smoke and air quality.Frontiers in toxicology · 2023Review
- Beyond genetics: can micro and nanoplastics induce epigenetic and gene-expression modifications?Frontiers in epigenetics and epigenomics · 2023Review
- Insect Models in Nutrition Research.Biomolecules · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The interactions of microplastics (MPs) with other chemicals and the range of outcomes are of great importance to enhance understanding of their environmental impacts and health risks. Cadmium (Cd) and cadmium compounds are widely used as pigments and stabilizers in plastics, but they readily leach out. Here we addressed the impacts of MPs, Cd, and their joint exposure in a tractable Drosophila melanogaster model. We show that exposure to MPs lead to extensive particle size depended gut damage early in life and an enhancement of Cd-induced inhibition of locomotor-behavioral function in adult flies. In addition, we show that Cd exposure induces epigenetic gene silencing via position-effect variegation (PEV) in somatic tissues that was dramatically enhanced by co-exposure with MPs. The results indicate that MPs can aggravate the toxicity of other environmental contaminants and induce adverse effects across a range of diverse outcomes in a tractable and widely used model organism. These observations raise the prospects of using Drosophila as a tool for the rapid assessment of MP-mediated toxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.