Evidence map›Paper›PMID 32721447›Full record

ArticleKidney international2021

Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery.

Steven Menez, Dennis G Moledina, Amit X Garg, Heather Thiessen-Philbrook, Eric McArthur, Yaqi Jia, Caroline Liu, Wassim Obeid, Sherry G Mansour, Jay L Koyner and 4 more

Abstract read
In one paragraph

Article in Kidney international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Long-term risks of adverse kidney outcomes after acute kidney injury: a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Pooled it
  2. Time Course of Kidney Injury Biomarkers in Children With Septic Shock: Nested Cohort Study Within the Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis Trial.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
    Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Kidney Injury Following Cardiac Surgery: A Review of Our Current Understanding.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
    Review
  11. Article
  12. Biomarker Panels for Predicting Progression of Kidney Disease in Acute Kidney Injury Survivors.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
  13. Article
  14. Article
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  16. Article
  17. Article
  18. Observational
  19. Article
  20. Integrated Analysis of Blood and Urine Biomarkers to Identify Acute Kidney Injury Subphenotypes and Associations With Long-term Outcomes.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Steven MenezDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dennis G MoledinaSection of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USA; Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Amit X GargDivision of Nephrology, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; ICES, Toronto, Ontario, Canada.
Heather Thiessen-PhilbrookDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Eric McArthurICES, Toronto, Ontario, Canada.
Yaqi JiaDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Caroline LiuDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Wassim ObeidDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sherry G MansourSection of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USA; Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Jay L KoynerSection of Nephrology, University of Chicago, Chicago, Illinois, USA.
Michael G ShlipakKidney Health Research Collaborative and Division of General Internal Medicine, San Francisco Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California, USA.
Francis P WilsonSection of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USA; Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Steven G CocaDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Chirag R ParikhDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: chirag.parikh@jhmi.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S. · 2008 to 2022
$16.8M
Novel Biomarkers in Cardiac Surgery to Detect Acute Kidney InjuryR01HL085757 · NHLBI · YALE UNIVERSITY · PI PARIKH, CHIRAG R · 2007 to 2019
$10.3M
Progression of Acute Kidney Injury to Chronic Kidney DiseaseU01DK082185 · NIDDK · YALE UNIVERSITY · PI PARIKH, CHIRAG R · 2008 to 2017
$5.1M
Optimizing Electronic Alerts for Acute Kidney InjuryR01DK113191 · NIDDK · YALE UNIVERSITY · PI WILSON, FRANCIS PERRY · 2018 to 2022
$3.1M
Impact of Exercise on Kidney Function and Injury among Elders in the LIFE TrialR01DK115562 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI COCA, STEVEN G, SHLIPAK, MICHAEL G · 2018 to 2020
$2.2M
Impact of early antiretroviral therapy on kidney disease outcomesR01DK112258 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WYATT, CHRISTINA M · 2017 to 2021
$2.1M
Linking the Effects of 9/11 to Kidney DiseaseU01OH011326 · OH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCLAUGHLIN, MARY A · 2017 to 2019
$1.5M
Leveraging Clinical Trials of Diabetic Kidney Disease to Advance BiomarkersU01DK106962 · NIDDK · YALE UNIVERSITY · PI COCA, STEVEN G, PARIKH, CHIRAG R · 2015 to 2019
$1.3M
Identification of Non-Invasive Biomarkers and Indices for Diagnosis of Drug-Induced Acute Interstitial NephritisK23DK117065 · NIDDK · YALE UNIVERSITY · PI MOLEDINA, DENNIS G. · 2018 to 2022
$920k
Mentoring Program for Translational and Patient Oriented Research in AKIK24DK090203 · NIDDK · YALE UNIVERSITY · PI PARIKH, CHIRAG R · 2012 to 2016
$896k
ACL HHS U01OH011326NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL085757NHLBI NIH HHS T32 HL007024NIDDK NIH HHS K23 DK117065NIDDK NIH HHS K24 DK090203NIDDK NIH HHS P30 DK079310NIDDK NIH HHS R01 DK112258NIDDK NIH HHS R01 DK113191NIDDK NIH HHS R01 DK115562NIDDK NIH HHS R21 DK113420NIDDK NIH HHS U01 DK082185NIDDK NIH HHS U01 DK106962NIOSH CDC HHS U01 OH011326
6 · The paper itself

Abstract

Patients undergoing cardiac surgery are placed under intense physiologic stress. Blood and urine biomarkers measured peri-operatively may help identify patients at higher risk for adverse long-term kidney outcomes.We sought to determine independent associations of various biomarkers with development or progression of chronic kidney disease (CKD) following cardiac surgery. In this sub-study of the prospective cohort -TRIBE-AKI Study, we evaluated 613 adult patients undergoing cardiac surgery in Canada in our primary analysis and tested the association of 40 blood and urinary biomarkers with the primary composite outcome of CKD incidence or progression. In those with baseline estimated glomerular filtration rate (eGFR) over 60 mL/min/1.73m

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresRenal Insufficiency, ChronicAdultBiomarkersCanadaDisease ProgressionGlomerular Filtration RateHumansProspective StudiesRisk FactorsUnited StatesBiomarkersbiomarkerscardiac surgeryCKDsubclinical AKI

Identifiers

PMID32721447
PMCPMC8077034

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.