Evidence map›Paper›PMID 32721425›Full record

ArticleExperimental eye research2020

PEDF deficiency increases the susceptibility of rd10 mice to retinal degeneration.

Shivani Dixit, Federica Polato, Marijana Samardzija, Mones Abu-Asab, Christian Grimm, Susan E Crawford, S Patricia Becerra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE.International journal of molecular sciences · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Delivery Systems of Retinoprotective Proteins in the Retina.International journal of molecular sciences · 2021
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shivani DixitSection of Protein Structure and Function, LRCMB-NEI-NIH, Bethesda, MD, USA.
Federica PolatoSection of Protein Structure and Function, LRCMB-NEI-NIH, Bethesda, MD, USA.
Marijana SamardzijaLaboratory of Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Zurich, Switzerland.
Mones Abu-AsabHistopathology Core, NEI-NIH, Bethesda, MD, USA.
Christian GrimmLaboratory of Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Zurich, Switzerland.
Susan E CrawfordDepartment of Surgery, NorthShore University Health System Research Institute, Evanston, IL, USA.
S Patricia BecerraSection of Protein Structure and Function, LRCMB-NEI-NIH, Bethesda, MD, USA. Electronic address: becerrap@nei.nih.gov.
National Institutes of Health · USUniversity of Zurich · CHNorthShore University HealthSystem · US

Funding

Therapeutics for the chorioretinaZIAEY000438 · NEI · NATIONAL EYE INSTITUTE · PI BECERRA, S. PATRICIA · 2009 to 2025
$6.7M
ROLE OF PROTEIN INTERACTIONS IN RETINA DEVELOPMENT AND FUNCTIONZ01EY000306 · NEI · NATIONAL EYE INSTITUTE · PI BECERRA, SOFIA P · 1995 to 2008
$2.3M
Protein therapeutics for the chorioretinaZ01EY000438 · NEI · NATIONAL EYE INSTITUTE · PI BECERRA, SOFIA P · 2006 to 2008
$1.5M
Intramural NIH HHS Z01 EY000306Intramural NIH HHS Z01 EY000438Intramural NIH HHS Z99 EY999999
6 · The paper itself

Abstract

The SERPINF1 gene encodes pigment epithelium-derived factor (PEDF), a member of the serpin superfamily with neurotrophic and antiangiogenic properties in the retina. We hypothesized that absence of PEDF would lead to increased stress-associated retinal degeneration in Serpinf1 null mice. Accordingly, using a Serpinf1 null mouse model, we investigated the impact of PEDF absence on retinal morphology, and susceptibility to induced and inherited retinal degeneration. We studied the pattern of Serpinf1 expression in the mouse retina layers. PEDF protein was detected by western blotting. Transmission electron microscopy was performed on mouse retina. Serpinf1 null mice and wild type littermates were injected with NaIO

Indexed as

AnimalsBlotting, WesternDisease Models, AnimalDisease ProgressionEye ProteinsMiceMice, Inbred C57BLMice, KnockoutNerve Growth FactorsPhotoreceptor Cells, VertebratePigment Epithelium-Derived FactorRetinal DegenerationRetinal Pigment EpitheliumSerpinsEye ProteinsNerve Growth FactorsPigment Epithelium-Derived FactorSerpinsNaIO(3)PEDFPigment epithelium-derived factorrd10Retinal degenerationSerpinf1

Identifiers

PMID32721425
PMCPMC7508969
OpenAlexW3044899312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.