ArticleeLife2020
Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- TUSC3 serves as a rate-limiting gatekeeper of a glycan-mediated ER triage checkpoint for BMP4/Dpp.Cell reports · 2026Article
- The STING pathway drives noninflammatory neurodegeneration in NGLY1 deficiency.The Journal of experimental medicine · 2025Article
- TUSC3 serves as a rate-limiting gatekeeper of a glycan-mediated ER Triage Checkpoint for BMP4/Dpp.bioRxiv : the preprint server for biology · 2025Article
- Natural SEL1L variants rescue a model of NGLY1 deficiency and modify ERAD function and proteasome sensitivity.PLoS genetics · 2025Article
- NGLY1 deficiency - clinical features and therapeutic strategy.Journal of human genetics · 2025Review
- Article
- Increased oxidative stress and autophagy in NGLY1 patient iPSC-derived neural stem cells.Experimental cell research · 2025Article
- Elucidation of the late steps in the glycan-dependent ERAD of soluble misfolded glycoproteins.The Plant journal : for cell and molecular biology · 2025Article
- Systemic gene therapy corrects the neurological phenotype in a mouse model of NGLY1 deficiency.JCI insight · 2024Article
- Development of new NGLY1 assay systems - toward developing an early screening method for NGLY1 deficiency.Glycobiology · 2024Review
- Development of a fluorescence and quencher-based FRET assay for detection of endogenous peptide:N-glycanase/NGLY1 activity.The Journal of biological chemistry · 2024Article
- Gut barrier defects, intestinal immune hyperactivation and enhanced lipid catabolism drive lethality in NGLY1-deficient Drosophila.Nature communications · 2023Article
- Topological regulation of a transmembrane protein by luminal-to-cytosolic retrotranslocation of glycosylated sequence.Cell reports · 2023Article
- N-glycoproteomics reveals distinct glycosylation alterations in NGLY1-deficient patient-derived dermal fibroblasts.Journal of inherited metabolic disease · 2023Article
- An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency.PLoS genetics · 2022Article
- Comprehensive Analysis of the Structure and Function of Peptide:N-Glycanase 1 and Relationship with Congenital Disorder of Deglycosylation.Nutrients · 2022Review
- NGLY1 Deficiency, a Congenital Disorder of Deglycosylation: From Disease Gene Function to Pathophysiology.Cells · 2022Review
- Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids.Cell death & disease · 2022Article
- A method for assaying peptide: N-glycanase/N-glycanase 1 activities in crude extracts using an N-glycosylated cyclopeptide.Glycobiology · 2022Article
- Ferroptosis regulation by the NGLY1/NFE2L1 pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 4 countries.
Antonio GaleoneDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Joshua M AdamsProgram in Developmental Biology, Baylor College of Medicine, Houston, United States.
Shinya MatsudaBiozentrum, University of Basel, Basel, Switzerland.ORCID 0000-0002-7541-7914
Maximiliano F PresaThe Jackson Laboratory, Bar Harbor, United States.
Ashutosh PandeyDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Seung Yeop HanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Yuriko TachidaGlycometabolome Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Saitama, Japan.
Hiroto HirayamaGlycometabolome Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Saitama, Japan.
Thomas VaccariDepartment of Biosciences, University of Milan, Milan, Italy.
Tadashi SuzukiGlycometabolome Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Saitama, Japan.
Cathleen M LutzThe Jackson Laboratory, Bar Harbor, United States.
Markus AffolterBiozentrum, University of Basel, Basel, Switzerland.ORCID 0000-0002-5171-0016
Aamir ZuberiThe Jackson Laboratory, Bar Harbor, United States.
Hamed Jafar-NejadDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-6403-3379
Baylor College of Medicine · USJackson Laboratory · USPioneer (Japan) · JPUniversity of Basel · CHUniversity of Milan · IT
Funding
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9MSteps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8MRoles of Glycosylation and Deglycosylation During Animal DevelopmentR35GM130317 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Hamed Jafar-Nejad · 2019 to 2026
$3.7MNICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIGMS NIH HHS R35 GM130317NIH HHS P40 OD018537Worldwide Cancer Research 18-0399
Abstract
During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme
Indexed as
AnimalsDrosophila melanogasterDrosophila ProteinsGene Expression RegulationGlycoproteinsGlycosylationSignal TransductionTranslocation, GeneticDrosophila ProteinsGlycoproteinsBMP signalingcell biologydeglycosylationdevelopmental biologyD. melanogasterERADmouseNGLY1N-glycosylationretrotranslocation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.