Evidence map›Paper›PMID 32720853›Full record

ArticlePhlebology2020

Safety of exercise therapy after acute pulmonary embolism.

Rafael S Cires-Drouet, Minerva Mayorga-Carlin, Shahab Toursavadkohi, Rachel White, Emily Redding, Frederick Durham, Kathleen Dondero, Steven J Prior, John D Sorkin, Brajesh K Lal

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Phlebology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07143539 (Early Exercise-based Rehabilitation in High-risk Patients Hospitalized for Acute Pulmonary Embolism), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07143539 narecruitingnot on this mapstarted 2025, after this paper: background citation

Early Exercise-based Rehabilitation in High-risk Patients Hospitalized for Acute Pulmonary Embolism: a Pragmatic Multicenter Randomized Partially Blinded Superiority Trial

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2025 to 2028Enrolled160ConditionsVenous Thromboembolism (VTE), Exercise Therapy, Quality of Life (QOL), Anxiety DepressionArmsExercise-based rehabilitation program
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Exercise and pulmonary embolism: a systematic review of exercise safety, feasibility and effectiveness.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Pulmonary embolism with chronic obstructive pulmonary disease.Chronic diseases and translational medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rafael S Cires-DrouetDivision of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-5051-9869
Minerva Mayorga-CarlinDivision of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD, USA.
Shahab ToursavadkohiDivision of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD, USA.
Rachel WhiteDivision of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD, USA.
Emily ReddingDivision of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD, USA.
Frederick DurhamDivision of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD, USA.
Kathleen DonderoDepartment of Kinesiology, Towson University, Baltimore, MD, USA.
Steven J PriorDivision of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
John D SorkinDivision of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Brajesh K LalDivision of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD, USA.

Funding

CREST-2 Clinical Coordinating CenterU01NS080168 · NINDS · MAYO CLINIC JACKSONVILLE · PI Thomas G Brott, JAMES F MESCHIA · 2014 to 2026
$56.3M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Healthy Aging Neighborhoods of Diversity Across LifespanZ01AG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2001 to 2008
$6.8M
Carotid Revascularization and Medical Management for Asymptomatic CarotidStenosis Trial - Hemodynamics (CREST-H)R01NS097876 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RONALD M LAZAR, DAVID SIGMUND LIEBESKIND · 2017 to 2026
$6.4M
New York Stroke Trials Network of Columbia and Cornell (NYCCSTN)U10NS086728 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARSHALL, RANDOLPH S · 2013 to 2017
$2.0M
CSRD VA I01 CX001621Intramural NIH HHS Z01 AG000513NIA NIH HHS P30 AG028747NIDDK NIH HHS P30 DK072488NINDS NIH HHS R01 NS097876NINDS NIH HHS U01 NS080168NINDS NIH HHS U10 NS086728RRD VA I01 RX000995
6 · The paper itself

Abstract

objectiveThe role of exercise therapy after acute pulmonary embolism (PE) is unknown. Exercise therapy is safely used after myocardial infarction and chronic obstructive pulmonary disease. The aim of this study was to investigate the safety of exercise therapy after acute PE.

methodsWe implemented a 3-month exercise program after acute PE. Outcomes were death, bleeding, readmissions, recurrent events, changes in peak VO2 and quality of life (QoL).

resultsA total of 23 patients were enrolled and received anticoagulation; no adverse events were reported during the exercise period. One death, 1 DVT and 5 readmissions were reported due to non-exercise related reasons. Functional capacity improved as evidenced by an increased peak VO2 at 3 months (+3.9 ± 5.6 mL/kg/min; p = 0.05). Improvement in QoL was observed at 6-months on the functional (+17.0 ± 22.6, p = 0.03) and physical health factor scales (+0.9 ± 4.6, p = 0.03).

conclusionExercise therapy is feasible and safe in appropriately anticoagulated patients after PE.

Indexed as

Exercise TherapyPulmonary EmbolismQuality of LifeAcute DiseaseAnticoagulantsFemaleHemorrhageHumansAnticoagulantsPulmonary embolismQuality of life assessmentVenous thromboembolism

Identifiers

PMID32720853
PMCPMC8209689

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.