Evidence map›Paper›PMID 32720760›Full record

ArticleMaternal & child nutrition2021

Maternal folate, one-carbon metabolism and pregnancy outcomes.

Tanja Jankovic-Karasoulos, Denise L Furness, Shalem Y Leemaqz, Gustaaf A Dekker, Luke E Grzeskowiak, Jessica A Grieger, Prabha H Andraweera, Dylan McCullough, Dale McAninch, Lesley M McCowan and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal & child nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 7 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 7 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Tanja Jankovic-KarasoulosRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0003-4293-359X
Denise L FurnessRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Shalem Y LeemaqzRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Gustaaf A DekkerRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Luke E GrzeskowiakRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0001-8554-4696
Jessica A GriegerRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Prabha H AndraweeraRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0003-2434-8370
Dylan McCulloughRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Dale McAninchRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Lesley M McCowanDepartment of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand.
Tina Bianco-MiottoRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Claire T RobertsRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-9250-2192
The University of Adelaide · AUFlinders University · AULyell McEwin Hospital · AUUniversity of Auckland · NZWine Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single nucleotide polymorphisms and pre- and peri-conception folic acid (FA) supplementation and dietary data were used to identify one-carbon metabolic factors associated with pregnancy outcomes in 3196 nulliparous women. In 325 participants, we also measured circulating folate, vitamin B12 and homocysteine. Pregnancy outcomes included preeclampsia (PE), gestational hypertension (GHT), small for gestational age (SGA), spontaneous preterm birth (sPTB) and gestational diabetes mellitus (GDM). Study findings show that maternal genotype MTHFR A1298C(CC) was associated with increased risk for PE, whereas TCN2 C766G(GG) had a reduced risk for sPTB. Paternal MTHFR A1298C(CC) and MTHFD1 G1958A(AA) genotypes were associated with reduced risk for sPTB, whereas MTHFR C677T(CT) genotype had an increased risk for GHT. FA supplementation was associated with higher serum folate and vitamin B12 concentrations, reduced uterine artery resistance index and increased birth weight. Women who supplemented with <800 μg daily FA at 15-week gestation had a higher incidence of PE (10.3%) compared with women who did not supplement (6.1%) or who supplemented with ≥800 μg (5.4%) (P < .0001). Higher serum folate levels were found in women who later developed GDM compared with women with uncomplicated pregnancies (Mean ± SD: 37.6 ± 8 nmol L

Indexed as

Folic AcidMaternal Nutritional Physiological PhenomenaPregnancy OutcomeCarbonFemaleHomocysteineHumansInfant, NewbornPregnancyPremature BirthUterine ArteryCarbonFolic AcidHomocysteinefolatefolic acidmaternal dietneonatal outcomesone-carbon metabolismpregnancy outcomesSNP

Identifiers

PMID32720760
PMCPMC7729528
OpenAlexW3046177493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.