ArticleeLife2020
Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study.Nature metabolism · 2023Trial
- Leptin-sensitive hypothalamic Lepr+/Glp1r+ neurons limit hyperphagia and weight gain in diet-induced obesity.The EMBO journal · 2026Article
- A hypothalamic circuit links hunger to mesolimbic dopamine to drive feeding.bioRxiv : the preprint server for biology · 2026Article
- Single-cell profiling identifies obesity-disrupted brain glucose sensing.Nature communications · 2026Article
- The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026Review
- Olfactory dysfunction in obesity and type 2 diabetes: mechanistic insights from preclinical models.Diabetologia · 2026Review
- Altered responses to ghrelin and food cues in AgRP neurons during pregnancy and lactation.Journal of neuroendocrinology · 2026Article
- Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Article
- Research Advances of Neuroregulatory Effects of Dietary Polyphenols on Obesity Complications.Nutrients · 2026Review
- Early ingestive experience with a high-fat diet tunes satiation and nutrient-specific appetitive behaviors.bioRxiv : the preprint server for biology · 2026Article
- Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice.Nature communications · 2026Article
- Fat sensory cues in early life program central response to food and obesity.Nature metabolism · 2025Article
- Aging reveals divergent responses of AgRP/NPY neurons to diet in male and female mice.bioRxiv : the preprint server for biology · 2025Article
- Metrics of glycemic control but not body weight influence flavor nutrient conditioning in humans.Physiology & behavior · 2025Article
- Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons.Scientific reports · 2025Article
- Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus.Journal of obesity & metabolic syndrome · 2025Review
- Neuroendocrinology and the Genetics of Obesity.Endocrinology · 2025Review
- A food-sensitive olfactory circuit drives anticipatory satiety.Nature metabolism · 2025Article
- Energy state guides reward seeking via an extended amygdala to lateral hypothalamus pathway.Nature communications · 2025Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Body weight is regulated by interoceptive neural circuits that track energy need, but how the activity of these circuits is altered in obesity remains poorly understood. Here we describe the in vivo dynamics of hunger-promoting AgRP neurons during the development of diet-induced obesity in mice. We show that high-fat diet attenuates the response of AgRP neurons to an array of nutritionally-relevant stimuli including food cues, intragastric nutrients, cholecystokinin and ghrelin. These alterations are specific to dietary fat but not carbohydrate or protein. Subsequent weight loss restores the responsiveness of AgRP neurons to exterosensory cues but fails to rescue their sensitivity to gastrointestinal hormones or nutrients. These findings reveal that obesity triggers broad dysregulation of hypothalamic hunger neurons that is incompletely reversed by weight loss and may contribute to the difficulty of maintaining a reduced weight.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.