ArticleeLife2020
An electrophysiological marker of arousal level in humans.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
204 citing papers in PubMed, 3 syntheses or guidelines pooled it, 417 citations in OpenAlex.
- A methodological guideline for consciousness assessment via neural electrophysiological activity.Military Medical Research · 2025Guideline
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Is criticality a unified setpoint of brain function?Neuron · 2025Pooled it
- Comprehensive Mitigation of Peripheral and Central Stress Responses by Nx4: Insights From EEG and Heart Rate Variability in Post-Stress Resting State.Human psychopharmacology · 2025Trial
- One-week escitalopram intake alters the excitation-inhibition balance in the healthy female brain.Human brain mapping · 2022Trial
- Detecting EEG index of arousal in sleeping patients with unresponsive wakefulness syndrome.iScience · 2026Article
- Inattention in Pediatric Attention-Deficit/Hyperactivity Disorder and Anxiety: Neurophysiological Evidence for Distinct and Overlapping Cognitive Mechanisms.Journal of attention disorders · 2026Article
- RIFT: A Fractal-Holographic Theory of Consciousness and Autopoietic Control.Brain sciences · 2026Article
- Baseline Dynamics and Sleep Loss-Driven Changes of Electrocorticographic Aperiodic Properties Are Altered in Mice Lacking Neuroligin-2.The European journal of neuroscience · 2026Article
- Shared Spectral Parameters Between EEG and Basal Ganglia LFP Distinguish Sleep-Specific Oscillations in Parkinson's Disease.European journal of neurology · 2026Article
- Pre-stimulus pupil-linked arousal enhances initial stimulus availability and accelerates decay in iconic memory.Attention, perception & psychophysics · 2026Article
- Beyond neural oscillations: Stress-related aperiodic activity and aperiodic-oscillatory spectral covariation.iScience · 2026Article
- Spontaneous changes in the prestimulus alpha power predict both objective and subjective aspects of perception-evidence from 4 paradigms and 471 experimental sessions.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Article
- Brainwaves under medication: revealing class-specific neural signatures of psychotropic medication from 24,000 EEGs.EBioMedicine · 2026Article
- Altered Evening Aperiodic Activity and Microstate Dynamics in Insomnia Disorder: An OPM MEG Study.CNS neuroscience & therapeutics · 2026Article
- A three-component dynamical index of consciousness-related neural organisation.Biological cybernetics · 2026Article
- Cognitive Processing and EEG Complexity.Entropy (Basel, Switzerland) · 2026Review
- Integrating multidimensional nociceptive-related cortical features for unsupervised assessment of anesthesia states in rats.iScience · 2026Article
- Aperiodic Dynamics of Cell Assemblies Recruited for L1 and L2 Processing of FrenchBrain sciences · 2026Article
144 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Deep non-rapid eye movement sleep (NREM) and general anesthesia with propofol are prominent states of reduced arousal linked to the occurrence of synchronized oscillations in the electroencephalogram (EEG). Although rapid eye movement (REM) sleep is also associated with diminished arousal levels, it is characterized by a desynchronized, 'wake-like' EEG. This observation implies that reduced arousal states are not necessarily only defined by synchronous oscillatory activity. Using intracranial and surface EEG recordings in four independent data sets, we demonstrate that the 1/f spectral slope of the electrophysiological power spectrum, which reflects the non-oscillatory, scale-free component of neural activity, delineates wakefulness from propofol anesthesia, NREM and REM sleep. Critically, the spectral slope discriminates wakefulness from REM sleep solely based on the neurophysiological brain state. Taken together, our findings describe a common electrophysiological marker that tracks states of reduced arousal, including different sleep stages as well as anesthesia in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.