Evidence map›Paper›PMID 32720632›Full record

ArticleThe American journal of tropical medicine and hygiene2020

Transcutaneous Vaccination with Conjugate Typhoid Vaccine Vi-DT Induces Systemic, Mucosal, and Memory Anti-Polysaccharide Responses.

Md Saruar Bhuiyan, Anuj Kalsy, Mohammad Arifuzzaman, Richelle C Charles, Jason B Harris, Stephen B Calderwood, Firdausi Qadri, Edward T Ryan

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Recent advances in enterotoxin vaccine adjuvants.Current opinion in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Md Saruar Bhuiyan1International Center for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Anuj Kalsy2Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.
Mohammad Arifuzzaman1International Center for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Richelle C Charles2Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.
Jason B Harris2Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.
Stephen B Calderwood2Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.
Firdausi Qadri1International Center for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Edward T Ryan2Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.

Funding

Training program in vaccine development and public healthD43TW005572 · FIC · MASSACHUSETTS GENERAL HOSPITAL · PI QADRI, FIRDAUSI, RYAN, EDWARD T. · 2000 to 2025
$5.4M
O-Specific Polysaccharide Responses and CholeraR01AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2014 to 2018
$3.7M
Detection of asymptomatic Salmonella enterica serotype Typhi and Paratyphi A carriage by serum antibodies targeting YncER01AI134814 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CHARLES, RICHELLE C · 2018 to 2022
$3.1M
Improving diagnostic capabilities for typhoid feverR33AI100023 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2014 to 2016
$987k
FIC NIH HHS D43 TW005572NIAID NIH HHS R01 AI106878NIAID NIH HHS R01 AI134814NIAID NIH HHS R33 AI100023
6 · The paper itself

Abstract

Transcutaneous vaccination can induce both mucosal and systemic immune responses. However, there are few data on anti-polysaccharide responses following transcutaneous vaccination of polysaccharides, despite the role that anti-polysaccharide responses play in protecting against intestinal mucosal and respiratory pathogens. Whether transcutaneous vaccination with a conjugate polysaccharide vaccine would be able to induce memory responses is also unknown. To address this, we transcutaneously vaccinated mice with virulence antigen (Vi) polysaccharide of

Indexed as

Administration, CutaneousAnimalsAntibodies, BacterialDisease Models, AnimalFemaleHumansImmunity, HumoralImmunity, MucosalImmunization ScheduleImmunoglobulin AImmunoglobulin GImmunologic MemoryMicePolysaccharides, BacterialSalmonella typhiTyphoid FeverAntibodies, BacterialImmunoglobulin AImmunoglobulin GPolysaccharides, BacterialTyphoid-Paratyphoid VaccinesVaccines, Conjugate

Identifiers

PMID32720632
PMCPMC7470581

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.