Evidence map›Paper›PMID 32720575›Full record

ArticleJournal of the American Heart Association2020

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice.

Lin-Juan Du, Jian-Yong Sun, Wu-Chang Zhang, Yong-Li Wang, Hong Zhu, Ting Liu, Ming-Zhu Gao, Chen Zheng, Yu-Yao Zhang, Yuan Liu and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Lin-Juan DuLaboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.
Jian-Yong SunLaboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.
Wu-Chang ZhangLaboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.
Yong-Li WangLaboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.
Hong ZhuLaboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.
Ting LiuLaboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.
Ming-Zhu GaoEngineering Research Center of Cell & Therapeutic Antibody Ministry of Education, and School of Pharmacy Shanghai Jiao Tong University Shanghai China.
Chen ZhengDepartment of Stomatology The Children's Hospital Zhejiang University School of Medicine Hangzhou China.
Yu-Yao ZhangLaboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.
Yuan LiuLaboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.
Yan LiuLaboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.
Shuai ShaoDepartment of Neurosurgery Ren Ji HospitalShanghai Jiao Tong University School of Medicine Shanghai China.
Xue-Qing ZhangEngineering Research Center of Cell & Therapeutic Antibody Ministry of Education, and School of Pharmacy Shanghai Jiao Tong University Shanghai China.
Qibin LengKey Laboratory of Molecular Virology and Immunology Institut Pasteur of Shanghai Shanghai Institutes for Biological Sciences Chinese Academy of SciencesUniversity of the Chinese Academy of Sciences Shanghai China.
Johan AuwerxLaboratory of Integrative and Systems Physiology Institute of Bioengineering École Polytechnique Fédérale de Lausanne (EPFL) Lausanne Switzerland.
Sheng-Zhong DuanLaboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.
Shanghai Jiao Tong University · CNChildren's Hospital of Zhejiang University · CNChinese Academy of Sciences · CNÉcole Polytechnique Fédérale de Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background NCOR1 (nuclear receptor corepressor 1) is an essential coregulator of gene transcription. It has been shown that NCOR1 in macrophages plays important roles in metabolic regulation. However, the function of macrophage NCOR1 in response to myocardial infarction (MI) or vascular wire injury has not been elucidated. Methods and Results Here, using macrophage

Indexed as

AnimalsBlotting, WesternDisease Models, AnimalFlow CytometryFluorescent Antibody TechniqueHyperplasiaMacrophagesMaleMiceMice, KnockoutMyocardial InfarctionNeointimaNuclear Receptor Co-Repressor 1Reverse Transcriptase Polymerase Chain ReactionNcor1 protein, mouseNuclear Receptor Co-Repressor 1inflammationmacrophage proliferationmyocardial infarctionneointimal hyperplasianuclear receptor corepressor 1

Identifiers

PMID32720575
PMCPMC7792266
OpenAlexW3045739168

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.