Observational studyJournal of orthopaedic research : official publication of the Orthopaedic Research Society2021
The AO trauma CPP bone infection registry: Epidemiology and outcomes of Staphylococcus aureus bone infection.
Observational study in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04455217 (Long--term Outcome Analysis of Fracture--related Infections), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long--term Outcome Analysis of Fracture--related Infections (Re_FRI)
Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Osteomyelitis: Epidemiology, Classification, Pathophysiology, Clinical Features, Diagnosis, and Management.MedComm · 2026Review
- Manganese enhances macrophage bactericidal activity in mice with Staphylococcus aureus osteomyelitis via Sirt3-mitophagy axis.Nature communications · 2026Article
- Low Percent Copper Doping Limits Bacterial Adhesion on Fluorapatite-Based Bone Scaffolds.Journal of biomedical materials research. Part B, Applied biomaterials · 2026Article
- Effects of hydroxybisphosphonates-conjugated sitafloxacin on fracture healing and skeletal growth in mice.JBMR plus · 2026Article
- Anti-IsdB Antibody-Secreting Cells Found in S. aureus-Infected Periprosthetic Bone Marrow: Case Series of Total Hip Arthroplasty Patients.Medical research archives · 2026Article
- Article
- Evaluating the safety, pharmacokinetics and efficacy of phage therapy in treating fracture-related infections with multidrug-resistantFrontiers in cellular and infection microbiology · 2025Article
- Immune Checkpoint Molecules as Biomarkers ofbioRxiv : the preprint server for biology · 2024Article
- EGFR-MEK1/2 cascade negatively regulates bactericidal function of bone marrow macrophages in mice with Staphylococcus aureus osteomyelitis.PLoS pathogens · 2024Article
- Time to Positivity in Blood Culture Bottles Inoculated with Sonication Fluid from Fracture-Related Infections.Microorganisms · 2024Article
- Longitudinal intravital imaging of the bone marrow for analysis of the race for the surface in a murine osteomyelitis model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Daptomycin-Impregnated PMMA Cement against Vancomycin-Resistant Germs: Dosage, Handling, Elution, Mechanical Stability, and Effectiveness.Antibiotics (Basel, Switzerland) · 2023Article
- Article
- Biofilms-What Should the Orthopedic Surgeon know?Indian journal of orthopaedics · 2023Review
- Low albumin level is more strongly associated with adverse outcomes and Staphylococcus aureus infection than hemoglobin A1C or smoking tobacco.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Fracture-related infection.Nature reviews. Disease primers · 2022Review
- The Medium Composition ImpactsInternational journal of molecular sciences · 2022Article
- Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation.Bone research · 2022Article
- Skeletal infections: microbial pathogenesis, immunity and clinical management.Nature reviews. Microbiology · 2022Review
- Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model ofFrontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
19 authors at 16 institutions in 10 countries.
Funding
Abstract
Bone infection represents a serious complication of orthopedic surgery and Staphylococcus aureus is the most common pathogen. To improve the understanding of host-pathogen interaction, we developed a biospecimen registry (AO Trauma CPP Bone Infection Registry) to collect clinical data, bacterial isolates, and serum from patients with S. aureus bone infection. A prospective multinational registry with a 12-month follow-up was created to include adult patients (18 years or older) with culture-confirmed S. aureus infection in long bones after fracture fixation or arthroplasty. Baseline patient attributes and details on infections and treatments were recorded. Blood and serum samples were obtained at baseline, 6, and 12 months. Patient-reported outcomes were collected at 1, 6, and 12 months. Clinical outcomes were recorded. Two hundred and ninety-two patients with fracture-related infection (n = 157, 53.8%), prosthetic joint infection (n = 86, 29.5%), and osteomyelitis (n = 49, 16.8%) were enrolled. Methicillin-resistant S. aureus was detected in 82 patients (28.4%), with the highest proportion found among patients from North American sites (n = 39, 48.8%) and the lowest from Central European sites (n = 18, 12.2%). Patient outcomes improved at 6 and 12 months in comparison to baseline. The SF-36 physical component summary mean (95% confidence interval) score, however, did not reach 50 at 12 months. The cure rate at the end of the study period was 62.1%. Although patients improved with treatment, less than two-thirds were cured in 1 year. At 12-month follow-up, patient-reported outcome scores were worse for patients with methicillin-resistant S. aureus infections.
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