ArticleBrain imaging and behavior2021
Self-reported experiences of discrimination in older black adults are associated with insula functional connectivity.
Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Racism and Older Black Americans' Health: a Systematic Review.Journal of urban health : bulletin of the New York Academy of Medicine · 2022Pooled it
- A systematic review of the neural correlates of sexual minority stress: towards an intersectional minority mosaic framework with implications for a future research agenda.European journal of psychotraumatology · 2022Pooled it
- Exploring the impact of immersive virtual reality on depression knowledge and stigma reduction: a cross-over RCT fMRI study.Scientific reports · 2024Trial
- Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults.GeroScience · 2022Trial
- Racism and alterations in brain structure and function: A narrative review of emerging neuroimaging evidence in racialized individuals.Cognitive, affective & behavioral neuroscience · 2026Review
- Anticipating Racism is Associated with Poorer Sleep Among Adults Racialized as Black.Journal of racial and ethnic health disparities · 2026Article
- Associations of Racial Discrimination with Resting-state Network Topology: A Mechanism for Post-traumatic Sensory Disruptions.Research square · 2026Article
- Associations between amygdala connectivity and experienced discrimination in children.bioRxiv : the preprint server for biology · 2026Article
- Racial Discrimination-Related Interoceptive Network Disruptions: A Pathway to Disconnection.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- The Scammers' Psychological Warfare: A Call to Arms.Psychological science in the public interest : a journal of the American Psychological Society · 2025Article
- Social exposome and brain health outcomes of dementia across Latin America.Nature communications · 2025Article
- Racial discrimination and anxiety in African American youth: Risk, resilience, and intervention.Journal of mood and anxiety disorders · 2025Review
- Introducing social determinants of health to the Alzheimer's Disease Research Center network: Development and implementation in the Uniform Data Set.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Racial Discrimination, Neural Connectivity, and Epigenetic Aging Among Black Women.JAMA network open · 2024Article
- The neurophysiological consequences of racism-related stressors in Black Americans.Neuroscience and biobehavioral reviews · 2024Review
- Discrimination and Cognition in Midlife Black Women: The Roles of Social Support and Spirituality.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- C-reactive protein moderates associations between racial discrimination and ventromedial prefrontal cortex activation during attention to threat in Black American women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Experiences of racial discrimination and adverse gene expression among black individuals in a level 1 trauma center sample.Brain, behavior, and immunity · 2024Article
- Looking Upstream to Understand Race/Ethnicity as a Moderator for Poststroke Neuroinflammation and a Social Determinant for Poststroke Aphasia Outcomes.American journal of speech-language pathology · 2024Article
- Sound-localization-related activation and functional connectivity of dorsal auditory pathway in relation to demographic, cognitive, and behavioral characteristics in age-related hearing loss.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Self-reported experiences of discrimination are associated with a number of negative health outcomes. However, the neurobiological correlates of discrimination remain elusive. Recent neuroimaging work suggests that the amygdala is sensitive to forms of social adversity and the insula is involved in assessments of trust. We hypothesized that functional connectivity (FC) of these brain regions may be associated with discrimination in older Black adults. One-hundred and twenty-four nondemented older Black adults participating in the Minority Aging Research Study or the Clinical Core study of the Rush Alzheimer's Disease Center completed a measure of self-reported experiences of discrimination and a 3T MRI brain scan including structural T1 and resting-state fMRI EPIBOLD sequences. The right and left amygdala and insula regions were anatomically delineated as ROIs according to the Harvard-Oxford Brain Atlas and whole-brain voxelwise FC analyses were conducted using default parameters in the CONN toolbox. In regression analyses controlling for demographics and global cognition, self-reported experiences of discrimination were associated with greater FC between the left insula and the bilateral intracalcarine cortex, weaker FC between the left insula and the left dorsolateral prefrontal cortex, and weaker FC between the right insula and the left supplementary motor area. Amygdala analyses yielded no significant findings. Greater self-reported experiences of discrimination are associated with differential insula functional connectivity in older adults. More specifically, results suggest that discrimination is associated with differential connectivity of a key region (the insula) involved in trust perception.
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Registered trials
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