Evidence map›Paper›PMID 32720055›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2021

SMARCA4 promotes benign skin malignant transformation into melanoma through Adherens junction signal transduction.

S-R Liu, X Yang, L Qi, Z Zhu, Y-Z Ji

Abstract read
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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

S-R LiuDepartment of Dermatology, The Second Hospital of Jilin University, No.218 Ziqiang Street, Nanguan District, Changchun, 130041, Jilin, People's Republic of China.
X YangDepartment of Urology, The Second Hospital of Jilin University, Changchun, 130041, Jilin, People's Republic of China.
L QiDepartment of Dermatology, The Second Hospital of Jilin University, No.218 Ziqiang Street, Nanguan District, Changchun, 130041, Jilin, People's Republic of China.
Z ZhuDepartment of Hand Surgery, The Second Hospital of Jilin University, Changchun, 130041, Jilin, People's Republic of China.
Y-Z JiDepartment of Dermatology, The Second Hospital of Jilin University, No.218 Ziqiang Street, Nanguan District, Changchun, 130041, Jilin, People's Republic of China. je1hh4@163.com.ORCID http://orcid.org/0000-0001-7575-5246
Second Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMelanoma is a malignant skin tumor, and its incidence is rising. To explore the specific differences in benign and malignant melanoma at the genetic level, we performed a series of bioinformatics analyses, including differential gene analysis, co-expression analysis, enrichment analysis, and regulatory prediction.

methodsThe microarray data of benign and malignant melanocytes were downloaded from GEO, and 1917 differential genes were obtained by differential analysis (p < 0.05). Weighted gene co-expression network analysis obtained three functional barrier modules. The essential genes of each module are SMARTA4, HECA, and C1R.

resultsThe results of the enrichment analysis showed that the dysfunctional module gene was mainly associated with RNA splicing and Adherens junction. Through the pivotal analysis of ncRNA, it was found that miR-448, miR-152-3p, and miR-302b-3p essentially regulate three modules, which we consider to be critical regulators. In the pivot analysis of TF, more control modules include ARID3A, E2F1, E2F3, and E2F8.

conclusionsWe believe that the regulator (miR-448, miR-152-3p, miR-302b-3p) regulates the expression of the core gene SMARCA4, which in turn affects the signal transduction of the Adherens junction. It eventually leads to the deterioration of benign skin spasms into melanoma.

Indexed as

MelanocytesAdherens JunctionsCell Transformation, NeoplasticComputational BiologyCutaneous Malignant MelanomaDatabases, GeneticDNA-Binding ProteinsDNA HelicasesE2F1 Transcription FactorE2F3 Transcription FactorGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMelanomaMicroRNAsARID3A protein, humanDNA-Binding ProteinsDNA HelicasesE2F1 protein, humanE2F1 Transcription FactorE2F3 protein, humanE2F3 Transcription FactorE2F8 protein, humanHECA protein, humanMicroRNAsMIRN152 microRNA, humanMIRN302A microRNA, humanMIRN448 microRNA, humanNeoplasm ProteinsNuclear ProteinsRepressor ProteinsRNA, MessengerRNA, UntranslatedSMARCA4 protein, humanTranscription FactorsAdherens junctionMelanomaSMARCA4WGCNA

Identifiers

PMID32720055
OpenAlexW3046121633

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.