Evidence map›Paper›PMID 32720036›Full record

ArticlePurinergic signalling2020

Design and in vivo activity of A

R Rama Suresh, Shanu Jain, Zhoumou Chen, Dilip K Tosh, Yanling Ma, Maren C Podszun, Yaron Rotman, Daniela Salvemini, Kenneth A Jacobson

Open access · greenAbstract read
In one paragraph

Article in Purinergic signalling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Purinergic Signaling in Non-Parenchymal Liver Cells.International journal of molecular sciences · 2024
    Review
  5. Cryo-EM structures of adenosine receptor ANature communications · 2024
    Article
  6. Review
  7. Knockout of Purinergic P2YInternational journal of molecular sciences · 2023
    Article
  8. Article
  9. Therapeutic Potential of Highly Selective AMolecules (Basel, Switzerland) · 2022
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Purinergic signaling in diabetes and metabolism.Biochemical pharmacology · 2021
    Review
  15. Purinergic Signaling in Liver Pathophysiology.Frontiers in endocrinology · 2021
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

R Rama SureshLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, 9000 Rockville Pike, Bethesda, MD, 20892-0810, USA.
Shanu JainLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, 9000 Rockville Pike, Bethesda, MD, 20892-0810, USA.
Zhoumou ChenDepartment of Pharmacology and Physiology, Saint Louis University, St. Louis, MO, USA.
Dilip K ToshLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, 9000 Rockville Pike, Bethesda, MD, 20892-0810, USA.
Yanling MaLiver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Maren C PodszunLiver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Yaron RotmanLiver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Daniela SalveminiDepartment of Pharmacology and Physiology, Saint Louis University, St. Louis, MO, USA.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, 9000 Rockville Pike, Bethesda, MD, 20892-0810, USA. kennethj@niddk.nih.gov.ORCID 0000-0001-8104-1493
National Institutes of Health · USNational Institute of Diabetes and Digestive and Kidney Diseases · USSaint Louis University · US

Funding

Nonalcoholic Steatohepatitis: Natural History, Pathogenesis and TherapyZIADK075013 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI ROTMAN, YARON · 2009 to 2025
$19.1M
Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Intramural NIH HHS ZIA DK075013NIDDK NIH HHS ZIADK31117NIDDK NIH HHS ZIADK75013
6 · The paper itself

Abstract

Prodrugs (MRS7422, MRS7476) of highly selective A

Indexed as

Drug DesignAdenosineAdenosine A3 Receptor AgonistsAnimalsDisease Models, AnimalInflammationMiceNeuralgiaNon-alcoholic Fatty Liver DiseaseProdrugs2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamideAdenosineAdenosine A3 Receptor AgonistsMRS5698ProdrugsAdenosine receptorNucleosidesPainProdrugPurinergic receptorsSteatohepatitis

Identifiers

PMID32720036
PMCPMC7524976
OpenAlexW3045870411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.