Evidence map›Paper›PMID 32719915›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study.

Matthieu Pelletier-Galarneau, Yoann Petibon, Chao Ma, Paul Han, Sally Ji Who Kim, Felicitas J Detmer, Daniel Yokell, Nicolas Guehl, Marc Normandin, Georges El Fakhri and 1 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03265431 (Evaluation of PET/MR in Patients Selected for Ablation Therapy), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03265431 phase2active not recruitingnot on this map

Evaluation of PET/MR in Patients Selected for Ablation Therapy

TypeinterventionalSponsorMassachusetts General HospitalRan2017 to 2027Enrolled34ConditionsArrhythmias, CardiacArms18F-TPP
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Molecular imaging: The bridge from human phenome to personalized precision medicine.European journal of nuclear medicine and molecular imaging · 2025
    Article
  4. Aging imaging: the future demand of health management.European journal of nuclear medicine and molecular imaging · 2023
    Article
  5. Review
  6. Review
  7. Biomarkers of aging.Science China. Life sciences · 2023
    Review
  8. Article
  9. Review
  10. Cardiac hybrid imaging: novel tracers for novel targets.Journal of geriatric cardiology : JGC · 2021
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Matthieu Pelletier-GalarneauDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA.
Yoann PetibonDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA.
Chao MaDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA.
Paul HanDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA.
Sally Ji Who KimDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA.
Felicitas J DetmerDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA.
Daniel YokellDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA.
Nicolas GuehlDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA.
Marc NormandinDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA.
Georges El FakhriDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA. ELFAKHRI.GEORGES@mgh.harvard.edu.
Nathaniel M AlpertDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, 125 Nashua Street, #6604, Boston, MA, 02114, USA. alpert@pet.mgh.harvard.edu.ORCID 0000-0002-5487-0234
Harvard University · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Postgraduate Training Program in Medical Imaging (PTPMI)T32EB013180 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Ciprian Catana, Pedram Heidari · 2011 to 2026
$3.7M
PET/MR Mapping of Myocardial Membrane PotentialR01HL137230 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES · 2017 to 2020
$3.3M
Permeability Imaging using Simultaneous Dynamic PET and Arterial Spin Labeling MRIK01EB030045 · NIBIB · YALE UNIVERSITY · PI HAN, PAUL KYU · 2020 to 2023
$497k
NHLBI NIH HHS R01 HL137230NIBIB NIH HHS K01 EB030045NIBIB NIH HHS P41 EB022544NIBIB NIH HHS T32 EB013180NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

purposeAlteration in mitochondrial membrane potential (ΔΨ

methodsThirteen healthy subjects were imaged using [

resultsIn 13 healthy subjects, average tissue membrane potential (ΔΨ

conclusionIn vivo quantification of the mitochondrial function has the potential to provide new diagnostic and prognostic information for several cardiac diseases as well as allowing therapy monitoring. This feasibility study lays the foundation for further investigations to assess these potential roles. Clinical trial identifier: NCT03265431.

Indexed as

Positron-Emission TomographyTomography, X-Ray ComputedFeasibility StudiesHumansMembrane PotentialsMyocardiumMitochondriaMitochondrial membrane potentialPositron emission tomographyTissue membrane potentialTriphenylphosphonium

Identifiers

PMID32719915
PMCPMC7839097
OpenAlexW3044107947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.