Evidence map›Paper›PMID 32719893›Full record

ArticlePlant cell reports2020

The life cycle of cyclotides: biosynthesis and turnover in plant cells.

Blazej Slazak, Tobias Haugmo, Bogna Badyra, Ulf Göransson

Open access · hybridAbstract read
In one paragraph

Article in Plant cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Blazej SlazakPharmacognosy, Department of Medicinal Chemistry, Biomedical Centre (BMC), Uppsala University, Box 574, 751 23, Uppsala, Sweden. b.slazak@botany.com.ORCID http://orcid.org/0000-0002-4143-6543
Tobias HaugmoPharmacognosy, Department of Medicinal Chemistry, Biomedical Centre (BMC), Uppsala University, Box 574, 751 23, Uppsala, Sweden.
Bogna BadyraW. Szafer Institute of Botany, Polish Academy of Sciences, 46 Lubicz St., 31-512, Cracow, Poland.
Ulf GöranssonPharmacognosy, Department of Medicinal Chemistry, Biomedical Centre (BMC), Uppsala University, Box 574, 751 23, Uppsala, Sweden.
Uppsala University · SEPolish Academy of Sciences · PL

Funding

Narodowe Centrum Nauki 2017/26/D/NZ8/00658Svenska Forskningsrådet Formas #2016-01474
6 · The paper itself

Abstract

key messageTurnover rates have implications for understanding cyclotide biology and improving plant cell culture-based production systems. Cyclotides are a family of polypeptides recognized for a broad spectrum of bioactivities. The cyclic, cystine knot structural motif imparts these peptides with resistance to temperature, chemicals and proteolysis. Cyclotides are found widely distributed across the Violaceae and in five other plant families, where their presumed biological role is host defense. Violets produce mixtures of different cyclotides that vary depending on the organ, tissue or influence of environmental factors. In the present study, we investigated the biosynthesis and turnover of cyclotides in plant cells. Viola uliginosa suspension cultures were grown in media where all nitrogen containing salts were replaced with their

Indexed as

Amino Acid SequenceChromatography, LiquidCyclotidesEndospermMass SpectrometryNitrogen IsotopesPlant CellsSeedlingsViolaCyclotidesNitrogen Isotopes15N labellingCyclic peptidesMass spectrometryPlant cell suspension cultureViola

Identifiers

PMID32719893
PMCPMC7497429
OpenAlexW3045727783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.