Evidence map›Paper›PMID 32719769›Full record

ReviewFrontiers in chemistry2020

Preparation of Complex Glycans From Natural Sources for Functional Study.

Qing Zhang, Zhonghua Li, Xuezheng Song

Abstract readReview
In one paragraph

Review in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Oxidative Release ofAnalytical chemistry · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qing ZhangDepartment of Biochemistry, Emory Comprehensive Glycomics Core, Emory University School of Medicine, Atlanta, GA, United States.
Zhonghua LiDepartment of Biochemistry, Emory Comprehensive Glycomics Core, Emory University School of Medicine, Atlanta, GA, United States.
Xuezheng SongDepartment of Biochemistry, Emory Comprehensive Glycomics Core, Emory University School of Medicine, Atlanta, GA, United States.

Funding

Novel Technologies for Quantitative O-glycomics and Amplification/Preparation of Cellular O-GlycansU01CA207821 · NCI · EMORY UNIVERSITY · PI SMITH, DAVID FLETCHER · 2016 to 2018
$1.9M
Facile Chemical Methods for Reverse Synthesis and Large Scale Production of Biomedically Relevant Glycan LibrariesU01GM116254 · NIGMS · EMORY UNIVERSITY · PI REINHOLD, VERNON NYE, SONG, XUEZHENG · 2015 to 2017
$1.6M
Natural Glycans for Functional GlycomicsR43GM133252 · NIGMS · NATGLYCAN, LLC · PI SMITH, DAVID FLETCHER · 2019 to 2019
$300k
A Natural Glycan Array of the Human Milk GlycomeR43GM131534 · NIGMS · NATGLYCAN, LLC · PI SMITH, DAVID FLETCHER · 2019 to 2020
$289k
Large Scale Preparation of Natural GlycansR41GM122139 · NIGMS · NATGLYCAN, LLC · PI SONG, XUEZHENG · 2017 to 2017
$286k
NCI NIH HHS U01 CA207821NIGMS NIH HHS R41 GM122139NIGMS NIH HHS R43 GM131534NIGMS NIH HHS R43 GM133252NIGMS NIH HHS U01 GM116254
6 · The paper itself

Abstract

One major barrier in glycoscience is the lack of diverse and biomedically relevant complex glycans in sufficient quantities for functional study. Complex glycans from natural sources serve as an important source of these glycans and an alternative to challenging chemoenzymatic synthesis. This review discusses preparation of complex glycans from several classes of glycoconjugates using both enzymatic and chemical release approaches. Novel technologies have been developed to advance the large-scale preparation of complex glycans from natural sources. We also highlight recent approaches and methods developed in functional and fluorescent tagging and high-performance liquid chromatography (HPLC) isolation of released glycans.

Indexed as

CORAHPLClarge scale preparationnatural glycansoxidative releasetagging

Identifiers

PMID32719769
PMCPMC7348041

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.