ArticleFrontiers in psychology2020
Cognition and Brain Activation in Response to Various Doses of Caffeine: A Near-Infrared Spectroscopy Study.
Article in Frontiers in psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- A systematic review and meta-analysis of the evidence on the acute effects of caffeine on sport-specific skills, physical performance, and physiological function in female basketball players.Frontiers in nutrition · 2026Pooled it
- Acute caffeine intervention and cognitive performance in populations aged 20 years and younger: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Pooled it
- Transcranial direct current stimulation combined with caffeine promotes executive function in healthy females.Journal of the International Society of Sports Nutrition · 2025Trial
- Effects of different doses of caffeine on cognitive performance in healthy physically active individuals.European journal of nutrition · 2024Trial
- Warm-up music and low-dose caffeine enhance the activity profile and psychophysiological responses during simulated combat in female taekwondo athletes.Scientific reports · 2024Trial
- Trial
- Trial
- Effects of Caffeine Intake on Cardiopulmonary Variables and QT Interval after a Moderate-Intensity Aerobic Exercise in Healthy Adults: A Randomized Controlled Trial.BioMed research international · 2022Trial
- Dose-Dependent Effects of Acute Caffeine Ingestion on Physical and Cognitive Performance in Trained Female Handball Players: A Randomized Crossover Study.Life (Basel, Switzerland) · 2026Article
- Effects of caffeinated chewing gum on prolonged repeated-sprint performance in normobaric hypoxia.Frontiers in nutrition · 2026Article
- Caffeine as a Modulator in Oncology: Mechanisms of Action and Potential for Adjuvant Therapy.International journal of molecular sciences · 2025Review
- Common questions and misconceptions about caffeine supplementation: what does the scientific evidence really show?Journal of the International Society of Sports Nutrition · 2024Review
- Timing Matters: Time of Day Impacts the Ergogenic Effects of Caffeine-A Narrative Review.Nutrients · 2024Review
- Effects of Various Caffeine Doses on Cognitive Abilities in Female Athletes with Low Caffeine Consumption.Brain sciences · 2024Article
- Nutrition, hydration and supplementation considerations for mountaineers in high-altitude conditions: a narrative review.Frontiers in sports and active living · 2024Review
- Diet, Supplementation and Nutritional Habits of Climbers in High Mountain Conditions.Nutrients · 2023Article
- Can Nutrients and Dietary Supplements Potentially Improve Cognitive Performance Also in Esports?Healthcare (Basel, Switzerland) · 2022Review
- Effects of Various Doses of Caffeine Ingestion on Intermittent Exercise Performance and Cognition.Brain sciences · 2020Article
- Caffeine and Exercise Performance: Possible Directions for Definitive Findings.Frontiers in sports and active living · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caffeine, which is widely used for enhancing athletic performance, has been suggested to have a positive impact on cognition via stimulating the brain. However, no study published to date has explored the effects of different doses of caffeine ingestion on brain activation via cortical hemodynamics. The purpose of the present crossover, double-blind study was to investigate the effects of low, moderate, and high doses of caffeine ingestion on cognitive performance and brain activation. Ten healthy male subjects ingested placebo or caffeine (3, 6, or 9 mg/kg body mass). The effects of each treatment condition were evaluated by Stroop tasks before and 60 min after the ingestion of caffeine. Reaction time (RT) and accuracy of responses to congruent and incongruent stimuli were assessed. As an index of brain activation with cognition, levels of oxygenated hemoglobin (HbO) were measured via near-infrared spectroscopy. A 4 × 2 mixed ANOVA revealed that there were significant interaction effects for RT in both incongruent and congruent conditions (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.