Evidence map›Paper›PMID 32719612›Full record

ReviewFrontiers in physiology2020

Potential Bidirectional Relationship Between Periodontitis and Alzheimer's Disease.

Daniela Liccardo, Federica Marzano, Federica Carraturo, Marco Guida, Grazia Daniela Femminella, Leonardo Bencivenga, Jacopo Agrimi, Armida Addonizio, Imma Melino, Alessandra Valletta and 4 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 6 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 6 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
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  7. Determinants of post-stroke cognitive impairment in patients with periodontal disease.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025
    Trial
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  15. Integrated transcriptomic profiling combined withFrontiers in aging neuroscience · 2026
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Daniela LiccardoDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Federica MarzanoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Federica CarraturoDepartment of Biology, University of Naples Federico II, Naples, Italy.
Marco GuidaDepartment of Biology, University of Naples Federico II, Naples, Italy.
Grazia Daniela FemminellaDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Leonardo BencivengaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Jacopo AgrimiDivision of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
Armida AddonizioDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Imma MelinoDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Alessandra VallettaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
Carlo RengoDepartment of Prosthodontics and Dental Materials, School of Dental Medicine, University of Siena, Siena, Italy.
Nicola FerraraDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Giuseppe RengoDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Alessandro CannavoDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
University of Naples Federico II · ITIstituti Clinici Scientifici Maugeri · ITJohns Hopkins University · USTemple University · USUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population, representing a global public health priority. Despite a large improvement in understanding the pathogenesis of AD, the etiology of this disorder remains still unclear, and no current treatment is able to prevent, slow, or stop its progression. Thus, there is a keen interest in the identification and modification of the risk factors and novel molecular mechanisms associated with the development and progression of AD. In this context, it is worth noting that several findings support the existence of a direct link between neuronal and non-neuronal inflammation/infection and AD progression. Importantly, recent studies are now supporting the existence of a direct relationship between periodontitis, a chronic inflammatory oral disease, and AD. The mechanisms underlying the association remain to be fully elucidated, however, it is generally accepted, although not confirmed, that oral pathogens can penetrate the bloodstream, inducing a low-grade systemic inflammation that negatively affects brain function. Indeed, a recent report demonstrated that oral pathogens and their toxic proteins infect the brain of AD patients. For instance, when AD progresses from the early to the more advanced stages, patients could no longer be able to adequately adhere to proper oral hygiene practices, thus leading to oral dysbiosis that, in turn, fuels infection, such as periodontitis. Therefore, in this review, we will provide an update on the emerging (preclinical and clinical) evidence that supports the relationship existing between periodontitis and AD. More in detail, we will discuss data attesting that periodontitis and AD share common risk factors and a similar hyper-inflammatory phenotype.

Indexed as

Alzheimer’s diseasedementiadysbiosisneurodegenerationperiodontitis

Identifiers

PMID32719612
PMCPMC7348667
OpenAlexW3039498094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.