Evidence map›Paper›PMID 32719599›Full record

ArticleFrontiers in pharmacology2020

Retinoic Acid Alleviates Cisplatin-Induced Acute Kidney Injury Through Activation of Autophagy.

Junxia Wu, Canbin Zheng, Xin Wan, Mingjun Shi, Kathryn McMillan, Jenny Maique, Changchun Cao

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Vitamin A and retinoid signaling in the kidneys.Pharmacology & therapeutics · 2023
    Review
  7. Review
  8. Liposoluble vitamins A and E in kidney disease.World journal of nephrology · 2022
    Review
  9. Review
  10. Review
  11. Disparate roles of retinoid acid signaling molecules in kidney disease.American journal of physiology. Renal physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junxia WuDepartment of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Canbin ZhengDepartment of Orthopedic and Microsurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xin WanDepartment of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Mingjun ShiDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Kathryn McMillanDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Jenny MaiqueDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Changchun CaoDepartment of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.

Funding

Klotho and Phosphate in Chronic Kidney Disease: Pathogenesis and TherapeuticsR01DK091392 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HU, MING-CHANG, MOE, ORSON W · 2011 to 2021
$3.2M
NIDDK NIH HHS R01 DK091392
6 · The paper itself

Abstract

Cisplatin-induced acute kidney injury (CIAKI) is a common complication in patients receiving cisplatin-based chemotherapy. But the effective therapies for CIAKI are not available. Retinoic acid (RA), the main derivative of vitamin A, has the potential to reduce inflammation and fibrosis in renal injury. However, the effect and mechanism of RA on CIAKI are still unclear. The aim of this study is to investigate whether RA can alleviate CIAKI through activation of autophagy. In this study, we evaluated the effect of RA, RA's effect on autophagy and apoptosis after cisplatin-induced injury on renal tubular epithelial cells (RTECs) by LDH assay, immunoblotting and TUNEL staining. Then we established Atg5

Indexed as

acute kidney injuryapoptosisautophagycisplatinretinoic acid

Identifiers

PMID32719599
PMCPMC7348052

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.