ArticleFrontiers in aging neuroscience2020
Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- Altered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing.CNS neuroscience & therapeutics · 2026Article
- Altered functional network topology and connectivity in female nurses with shift work sleep disorder.Frontiers in systems neuroscience · 2025Article
- Additive effects of cerebrovascular disease functional connectome phenotype and plasma p-tau181 on longitudinal neurodegeneration and cognitive outcomes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Long-range connections damage in white matter hyperintensities affects information processing speed.Brain communications · 2024Article
- Decreased Local Specialization of Brain Structural Networks Associated with Cognitive Dysfuntion Revealed by Probabilistic Diffusion Tractography for Different Cerebral Small Vessel Disease Burdens.Molecular neurobiology · 2024Article
- Topologic Efficiency Abnormalities of the Connectome in Asymptomatic Patients with Leukoaraiosis.Brain sciences · 2022Article
- Disrupted topological organization of resting-state functional brain networks in cerebral small vessel disease.Human brain mapping · 2022Article
- Impaired functional network properties contribute to white matter hyperintensity related cognitive decline in patients with cerebral small vessel disease.BMC medical imaging · 2022Article
- Effects of Motor Imagery Tasks on Brain Functional Networks Based on EEG Mu/Beta Rhythm.Brain sciences · 2022Article
- Comorbid depressive symptoms can aggravate the functional changes of the pain matrix in patients with chronic back pain: A resting-state fMRI study.Frontiers in aging neuroscience · 2022Article
- Focal Subcortical White Matter Lesions Disrupt Resting State Cortical Interhemispheric Functional Connectivity in Mice.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- The 2-D Cluster Variation Method: Topography Illustrations and Their Enthalpy Parameter Correlations.Entropy (Basel, Switzerland) · 2021Article
- Aging Brains Degrade Driving Safety Performances of the Healthy Elderly.Frontiers in aging neuroscience · 2021Article
- Neuroimaging Anomalies in Community-Dwelling Asymptomatic Adults With Very Early-Stage White Matter Hyperintensity.Frontiers in aging neuroscience · 2021Article
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9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive impairment is a key clinical feature of ischemic leukoaraiosis (ILA); however, the underlying neurobiological mechanism is still unclear. ILA has been associated with widespread gray and white matter (WM) damage mainly located in cortical-cortical and cortico-subcortical pathways. A total of 36 patients with ILA (Fazekas rating score ≥2) and 31 healthy controls (HCs) underwent comprehensive neuropsychological assessments (covering four cognitive domains, i.e., information processing speed, episodic memory, executive and visuospatial function) and resting-state functional MRI scans. Graph theory-based analyses were employed to explore the topological organization of the brain connectome in ILA patients, and we further sought to explore the associations of connectome-based metrics and neuropsychological performances. An efficient small-world architecture in the functional brain connectome was observed in the ILA and control groups. Moreover, compared with the HCs, the ILA patients showed increased path length and decreased network efficiency (i.e., global and local efficiency) in their functional brain networks. Further network-based statistic (NBS) analysis revealed a functional-disconnected network in ILA, which is comprised of functional connections linking different brain modules (i.e., default mode, frontoparietal, ventral attention and limbic systems) and connections within single modules (i.e., ventral attention and limbic systems). Intriguingly, the abnormal network metrics correlated with cognitive deficits in ILA patients. Therefore, our findings provide further evidence to support the concept that ILA pathologies could disrupt brain connections, impairing network functioning, and cognition
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