ArticleFrontiers in cellular neuroscience2020
Mechanisms of Axon Elongation Following CNS Injury: What Is Happening at the Axon Tip?
Article in Frontiers in cellular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Combining Therapeutic Strategies to Treat the Injured Spinal Cord: A Translational Perspective.Journal of neurotrauma · 2025Review
- Bltp1 Is Required for Survival and Normal Development and Function of the Neuromuscular Junction in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Netrin-1 as A neural guidance protein in development and reinnervation of the larynx.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2024Review
- TPP-Based Microfluidic Chip Design and Fabrication Method for Optimized Nerve Cells Directed Growth.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Review
- Nanosuspension of Foeniculum Vulgare Promotes Accelerated Sensory and Motor Function Recovery after Sciatic Nerve Injury.Metabolites · 2023Article
- Therapeutic Potential of "Smart" Exosomes in Peripheral Nerve Regeneration.Journal of biotechnology and biomedicine · 2023Article
- JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth.Neurochemical research · 2022Article
- Axon Regeneration: A Subcellular Extension in Multiple Dimensions.Cold Spring Harbor perspectives in biology · 2022Review
- Cholesterol synthesis inhibition or depletion in axon regeneration.Neural regeneration research · 2022Review
- The Role of Spastin in Axon Biology.Frontiers in cell and developmental biology · 2022Review
- Establishing neuronal polarity: microtubule regulation during neurite initiation.Oxford open neuroscience · 2022Review
- Exosomes as a Promising Therapeutic Strategy for Peripheral Nerve Injury.Current neuropharmacology · 2021Review
- Establishment of Long-Term Primary Cortical Neuronal Cultures From Neonatal OpossumFrontiers in cellular neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
After an injury to the central nervous system (CNS), functional recovery is limited by the inability of severed axons to regenerate and form functional connections with appropriate target neurons beyond the injury. Despite tremendous advances in our understanding of the mechanisms of axon growth, and of the inhibitory factors in the injured CNS that prevent it, disappointingly little progress has been made in restoring function to human patients with CNS injuries, such as spinal cord injury (SCI), through regenerative therapies. Clearly, the large number of overlapping neuron-intrinsic and -extrinsic growth-inhibitory factors attenuates the benefit of neutralizing any one target. More daunting is the distances human axons would have to regenerate to reach some threshold number of target neurons, e.g., those that occupy one complete spinal segment, compared to the distances required in most experimental models, such as mice and rats. However, the difficulties inherent in studying mechanisms of axon regeneration in the mature CNS
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