Evidence map›Paper›PMID 32719562›Full record

ArticleNature neuroscience2020

Posterior amygdala regulates sexual and aggressive behaviors in male mice.

Takashi Yamaguchi, Dongyu Wei, Soomin C Song, Byungkook Lim, Nicolas X Tritsch, Dayu Lin

Open access · greenAbstract read
In one paragraph

Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
  2. Neural basis of social hierarchy across species.Nature reviews. Neuroscience · 2026
    Review
  3. Article
  4. The hormonal and neural control of maternal aggression.Current opinion in neurobiology · 2026
    Review
  5. Sexual Dimorphism in c-Fos Networks Governing Aggression.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Neural plasticity supporting parental behaviors.Current opinion in neurobiology · 2025
    Review
  8. Context rescales a social action code in a hormone-sensitive network.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Review
  11. Estrogen Control of Social Behaviors.Annual review of neuroscience · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Developmental Shifts in Amygdala Function.Current topics in behavioral neurosciences · 2025
    Review
  17. An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Takashi YamaguchiNeuroscience Institute, New York University Langone Medical Center, New York, NY, USA. takashi.yamaguchi@nyulangone.org.ORCID http://orcid.org/0000-0001-5153-940X
Dongyu WeiNeuroscience Institute, New York University Langone Medical Center, New York, NY, USA.
Soomin C SongNeuroscience Institute, New York University Langone Medical Center, New York, NY, USA.
Byungkook LimNeurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3766-5415
Nicolas X TritschNeuroscience Institute, New York University Langone Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-3181-7681
Dayu LinNeuroscience Institute, New York University Langone Medical Center, New York, NY, USA. dayu.lin@nyulangone.org.ORCID http://orcid.org/0000-0003-2006-0791
NYU Langone Health · USUniversity of California San Diego · US

Funding

U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOSES VICTOR CHAO · 2018 to 2026
$36.4M
Research Supplement to Promote Diversity in Health-Related ResearchR01MH101377 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dayu Lin · 2013 to 2026
$8.6M
A novel framework for the functional dissection of motor systemsDP2NS105553 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRITSCH, NICOLAS XAVIER · 2017 to 2017
$2.5M
Dissecting the neural circuits of maternal behaviorsR01HD092596 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIN, DAYU · 2018 to 2022
$2.4M
The Neural Basis of Social Stress-induced DepressionR01MH107742 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIM, BYUNGKOOK · 2015 to 2019
$2.2M
The Projection specific roles of ventral pallidal parvalbumin-positive neurons in social defeat stress-induced depressionR01MH108594 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIM, BYUNGKOOK · 2016 to 2019
$927k
Dopaminergic modulation of brain circuits that control movementR00NS087098 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRITSCH, NICOLAS XAVIER · 2016 to 2018
$747k
Understand the neural mechanism underlying aggressive motivationR21MH105774 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIN, DAYU · 2016 to 2017
$466k
NICHD NIH HHS R01 HD092596NIMH NIH HHS R01 MH101377NIMH NIH HHS R01 MH107742NIMH NIH HHS R01 MH108594NIMH NIH HHS R21 MH105774NINDS NIH HHS DP2 NS105553NINDS NIH HHS R00 NS087098NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

Sexual and aggressive behaviors are fundamental to animal survival and reproduction. The medial preoptic nucleus (MPN) and ventrolateral part of the ventromedial hypothalamus (VMHvl) are essential regions for male sexual and aggressive behaviors, respectively. While key inhibitory inputs to the VMHvl and MPN have been identified, the extrahypothalamic excitatory inputs essential for social behaviors remain elusive. Here we identify estrogen receptor alpha (Esr1)-expressing cells in the posterior amygdala (PA) as a main source of excitatory inputs to the hypothalamus and key mediators for mating and fighting in male mice. We find two largely distinct PA subpopulations that differ in connectivity, gene expression, in vivo responses and social behavior relevance. MPN-projecting PA

Indexed as

AggressionAmygdalaAnimalsHypothalamusMaleMiceNeural PathwaysNeuronsSexual Behavior, Animal

Identifiers

PMID32719562
PMCPMC7483354
OpenAlexW3045118514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.