ArticleNature metabolism2020
Profound and redundant functions of arcuate neurons in obesity development.
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Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
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Who cites it
72 citing papers in PubMed, 104 citations in OpenAlex.
- Article
- Reduced melanocortin tone modulates feeding during pregnancy in mice.Nature communications · 2026Article
- Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.Stem cell reports · 2026Article
- A Hypothalamic Inhibitory Circuit Encoding the Scalability of Stress Responses.bioRxiv : the preprint server for biology · 2026Article
- A dual-pathway dysregulation in prefrontal-habenular circuits mediates stress susceptibility.Nature communications · 2026Article
- Beyond satiety: unraveling the complex roles of POMC neurons in behavior and metabolism.Reviews in endocrine & metabolic disorders · 2026Review
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.Metabolism: clinical and experimental · 2026Article
- Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Selective and differential roles of PVHNature communications · 2026Article
- Identification of a neural basis for anorexia nervosa.bioRxiv : the preprint server for biology · 2026Article
- The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition.Nature communications · 2026Article
- GLP-1 physiology and pharmacology along the gut-brain axis.The Journal of clinical investigation · 2026Review
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.bioRxiv : the preprint server for biology · 2025Article
- The effect of alpha lipoic acid and caffeine loaded into chitosan nanoparticles on the hypothalamic amino acid neurotransmitters in a rat model of obesity.Scientific reports · 2025Article
- A hypothalamic circuit for anticipating future changes in energy balance.bioRxiv : the preprint server for biology · 2025Article
- Prolonged exposure to food odors suppresses feeding via an olfactory bulb-to-hypothalamus circuit.Nature communications · 2025Article
- Uncovering the role of Gpr45 in obesity regulation.Molecular metabolism · 2025Article
- Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus.Journal of obesity & metabolic syndrome · 2025Review
- An alternative neural basis underlying leptin resistance.Cell reports · 2025Article
- AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway.Cell & bioscience · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Canjun ZhuBrown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-1620-3414
Zhiying JiangBrown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Yuanzhong XuBrown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5264-5324
Zhao-Lin CaiDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-4034-2884
Qingyan JiangGuangdong Province Key Laboratory of Animal Nutritional Regulation, College of Animal Science, South China Agricultural University, Guangdong, China.ORCID http://orcid.org/0000-0003-3466-2443
Yong XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4908-1572
Mingshan XueDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-1463-8884
Benjamin R ArenkielDepartment of Molecular and Human Genetics and Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Qi WuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0303-4065
Gang ShuGuangdong Province Key Laboratory of Animal Nutritional Regulation, College of Animal Science, South China Agricultural University, Guangdong, China. shugang@scau.edu.cn.ORCID http://orcid.org/0000-0002-1321-4396
Qingchun TongBrown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. Qingchun.tong@uth.tmc.edu.ORCID http://orcid.org/0000-0002-4561-2540
Brown Foundation · USBaylor College of Medicine · USSouth China Agricultural University · CNChildren's Nutrition Research Center at Baylor College of Medicine · US
Funding
UM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9MSteps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8MR01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4MMETABOLIC IMPACTS OF TYPE II INTERFERON SIGNALS IN OBESITYR01DK114356 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2017 to 2025
$4.6MActivity-Dependent Mechanisms Regulating Synaptic Excitation and Inhibition in Neural CircuitsR01MH117089 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI XUE, MINGSHAN · 2018 to 2022
$2.0MNeurobiology for the sex differences in energy balanceR01DK117281 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2018 to 2022
$1.8MA Novel AgRP Neurons to the Dorsal Raphe Circuit in Control of Energy ExpenditureR01DK109194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WU, QI · 2017 to 2021
$1.8MA direct LH to PVH projection for antagonistic regulation of feedingR01DK114279 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2018 to 2021
$1.5MTargeting hypothalamic steroid receptor co-activator-1 to treat obesityR01DK101379 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2014 to 2017
$1.2MTo explore the mechanism underlying developmental compensations in PVH neuronsR21NS108091 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2019 to 2019
$426kA Novel AgRP Neurons to the Dorsal Raphe Circuit in Control of Energy ExpenditureR56DK109194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WU, QI · 2016 to 2016
$105kNHGRI NIH HHS UM1 HG006348NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIDDK NIH HHS R01 DK101379NIDDK NIH HHS R01 DK109194NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK114279NIDDK NIH HHS R01 DK114356NIDDK NIH HHS R01 DK117281NIDDK NIH HHS R56 DK109194NIMH NIH HHS R01 MH117089NINDS NIH HHS R21 NS108091
Abstract
The current obesity epidemic faces a lack of mechanistic insights. It is known that the acute activity changes of a growing number of brain neurons rapidly alter feeding behaviour; however, how these changes translate to obesity development and the fundamental mechanism underlying brain neurons in controlling body weight remain elusive. Here, we show that chronic activation of hypothalamic arcuate GABAergic (GABA
Indexed as
AgingAgouti-Related ProteinAnimalsArcuate Nucleus of HypothalamusBody WeightEatingEnergy MetabolismFemalegamma-Aminobutyric AcidLeptinMaleMiceMice, ObeseNeuronsObesityWeight GainAgouti-Related ProteinAgrp protein, mousegamma-Aminobutyric AcidLeptin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.