ArticleNature metabolism2020
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.
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In one paragraph
Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- Factors Influencing AMPK Activation During Cycling Exercise: A Pooled Analysis and Meta-Regression.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Furan fatty acids reprogram hepatic lipid metabolism via acyl-CoA conjugates in obesity.Science advances · 2026Article
- Lipid dynamics shape thermogenic adaptation in brown fat during fasting.Journal of lipid research · 2026Article
- Obesity-related palmitic acid exacerbates IL-13-induced mucus phenotype in 16HBE airway epithelial cells via AMPK suppression.Translational pediatrics · 2026Article
- AMPK Therapy-A Little Goes A Long Way.Cells · 2026Review
- Acbd7 is essential for preserving hair cell-mediated auditory and vestibular function.Experimental & molecular medicine · 2026Article
- The yeast mitochondrial porin represses Snf1/AMP kinase signaling to attenuate viral replication.Genetics · 2026Article
- De Novo Lipogenesis in Clear Cell Renal Cell Carcinoma: Mechanistic Insights and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Amino acid insufficiency orchestrates AMPK and mTOR signaling.Fundamental research · 2026Article
- Often forgotten but essential: long-chain acyl-CoAs in metabolic control.Nature metabolism · 2026Article
- UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration.Nature neuroscience · 2026Article
- Metabolic dysfunction-associated steatotic liver disease and steatohepatitis-associated hepatocarcinoma preclinical models.Nature reviews. Gastroenterology & hepatology · 2026Review
- AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis.Nature metabolism · 2026Review
- Mitochondrial dysfunction and lipid droplet dynamics in MASH: HSD17B13 as a therapeutic target.Frontiers in cell and developmental biology · 2026Review
- AMPK agonism optimizes the in vivo activation and antileukemic efficacy of chimeric antigen receptor T cells.Journal for immunotherapy of cancer · 2025Article
- Interaction Between Microglial Lipid Droplet Metabolism and Immune Polarisation After Stroke: Mechanisms and Therapeutic Prospects.Cellular and molecular neurobiology · 2025Review
- KAT6A acetylation regulates AMPK function and hypertrophic remodeling in the heart.Molecular metabolism · 2025Article
- The AMPK Pathway: Molecular Rejuvenation of Metabolism and Mitochondria.Annual review of cell and developmental biology · 2025Review
- Molecular targets of bempedoic acid and related decoy fatty acids.Trends in endocrinology and metabolism: TEM · 2025Review
- MASH: the nexus of metabolism, inflammation, and fibrosis.The Journal of clinical investigation · 2025Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 4 institutions in 3 countries.
Stephen L Pinkosky *Centre for Metabolism, Obesity and Diabetes Research and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
John W Scott *Protein Chemistry & Metabolism, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.ORCID http://orcid.org/0000-0002-1896-9798
Eric M DesjardinsCentre for Metabolism, Obesity and Diabetes Research and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Brennan K SmithCentre for Metabolism, Obesity and Diabetes Research and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Emily A DayCentre for Metabolism, Obesity and Diabetes Research and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-3245-5715
Rebecca J FordCentre for Metabolism, Obesity and Diabetes Research and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Christopher G LangendorfProtein Chemistry & Metabolism, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.
Naomi X Y LingMetabolic Signalling Laboratory, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.ORCID http://orcid.org/0000-0001-6240-4092
Tracy L NeroACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.ORCID http://orcid.org/0000-0002-3393-1843
Kim LohProtein Chemistry & Metabolism, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.
Sandra GalicProtein Chemistry & Metabolism, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.
Ashfaqul HoqueMetabolic Signalling Laboratory, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.ORCID http://orcid.org/0000-0003-2384-2983
William J SmilesMetabolic Signalling Laboratory, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.ORCID http://orcid.org/0000-0002-6846-689X
Kevin R W NgoeiProtein Chemistry & Metabolism, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.
Michael W ParkerACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.ORCID http://orcid.org/0000-0002-3101-1138
Yan YanCenter for Cancer and Cell Biology, Structural Biology Program, Van Andel Research Institute, Grand Rapids, MI, USA.
Karsten MelcherCenter for Cancer and Cell Biology, Structural Biology Program, Van Andel Research Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-9125-4027
Bruce E KempProtein Chemistry & Metabolism, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.ORCID http://orcid.org/0000-0001-6735-5082
Jonathan S OakhillMary MacKillop Institute for Health Research, Australian Catholic University, Fitzroy, Victoria, Australia. joakhill@svi.edu.au.ORCID http://orcid.org/0000-0002-9475-1440
Gregory R SteinbergCentre for Metabolism, Obesity and Diabetes Research and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada. gsteinberg@mcmaster.ca.ORCID http://orcid.org/0000-0001-5425-8275
The University of Melbourne · AUMcMaster University · CAVan Andel Institute · USMcMaster University Medical Centre · CA
Funding
Structural interrogation of allosteric AMPK regulationR01GM104212 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI MELCHER, KARSTEN · 2013 to 2016
$1.5MStructural Mechanisms of AMPK RegulationR01GM129436 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI MELCHER, KARSTEN · 2018 to 2019
$767kCIHR 201709FDN-CEBA-116200NIGMS NIH HHS R01 GM104212NIGMS NIH HHS R01 GM129436
Abstract
Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and signalling molecules
Indexed as
Acyl Coenzyme AAllosteric RegulationAMP-Activated Protein KinasesAnimalsBiphenyl CompoundsCatalytic DomainEstersIsoenzymesMaleMiceMice, Inbred C57BLModels, MolecularMutationOxidation-ReductionPalmitoyl Coenzyme APhosphorylation4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrileAcyl Coenzyme AAMP-Activated Protein KinasesBiphenyl CompoundsEstersIsoenzymesPalmitoyl Coenzyme APrkab1 protein, mousePyronesThiophenes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.