Evidence map›Paper›PMID 32719476›Full record

ArticleScientific reports2020

Age-dependent regional retinal nerve fibre changes in SIX1/SIX6 polymorphism.

Jason Charng, Mark Simcoe, Paul G Sanfilippo, R Rand Allingham, Alex W Hewitt, Chris J Hammond, David A Mackey, Seyhan Yazar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Jason CharngCentre for Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, 2 Verdun St, Perth, WA, 6009, Australia.
Mark SimcoeDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Paul G SanfilippoCentre for Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, 2 Verdun St, Perth, WA, 6009, Australia.
R Rand AllinghamDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Alex W HewittCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, 3002, Australia.
Chris J HammondDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
David A MackeyCentre for Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, 2 Verdun St, Perth, WA, 6009, Australia.
Seyhan YazarCentre for Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, 2 Verdun St, Perth, WA, 6009, Australia. SeyhanYazar@lei.org.au.
King's College London · GBUniversity of Western Australia · AUDuke Medical Center · USGarvan Institute of Medical Research · AULions Eye Institute · AUUniversity of Melbourne · AU

Funding

CIHRDepartment of HealthMedical Research CouncilWellcome Trust
6 · The paper itself

Abstract

SIX1/SIX6 polymorphism has been shown to be associated with glaucoma. Studies have also found that, in older adults, retinal nerve fibre layer (RNFL) thickness is significantly thinned with each copy of the risk allele in SIX1/SIX6. However, it is not known whether these genetic variants exert their effects in younger individuals. Comparing a healthy young adult with an older adult cohort (mean age 20 vs 63 years), both of Northern European descent, we found that there was no significant RNFL thinning in each copy of the risk alleles in SIX1/SIX6 in the eyes of younger individuals. The older cohort showed an unexpectedly thicker RNFL in the nasal sector with each copy of the risk allele for both the SIX1 (rs10483727) and SIX6 (rs33912345) variants. In the temporal sector, thinner RNFL was found with each copy of the risk allele in rs33912345 with a decrease trend observed in rs10483727. Our results suggest that SIX1/SIX6 gene variants exert their influence later in adult life.

Indexed as

AdultAgedAgingFemaleGenetic Association StudiesHomeodomain ProteinsHumansMaleMiddle AgedNerve FibersPolymorphism, Single NucleotideRetinaTrans-ActivatorsYoung AdultHomeodomain ProteinsSIX1 protein, humanSIX6 protein, humanTrans-Activators

Identifiers

PMID32719476
PMCPMC7385166
OpenAlexW3044202699

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.