ArticleScientific reports2020
Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01226784 (The Effects of Training and Relaxation on Fibromyalgia.), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Training and Relaxation on Fibromyalgia.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies.Current pain and headache reports · 2024Pooled it
- An explorative cross-sectional study on the association between immunological biomarkers in patients with chronic pain.Brain, behavior, & immunity - health · 2026Article
- Non-Invasive Electrochemical Biosensors for Fibromyalgia: A Path Toward Objective Physiological Monitoring and Personalized Management.Sensors (Basel, Switzerland) · 2026Review
- Translation and Validation of the Greek Version of the Revised Fibromyalgia Impact Questionnaire (FIQR).Mediterranean journal of rheumatology · 2026Article
- An Exploratory Study for Proteomic-Based Markers of Joint Pain and Chronic Back Pain.European journal of pain (London, England) · 2025Article
- Proteomic Profiling Reveals Novel Molecular Insights into Dysregulated Proteins in Established Cases of Rheumatoid Arthritis.Proteomes · 2025Article
- Large-Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- How does chronic psychosocial distress induce pain? Focus on neuroinflammation and neuroplasticity changes.Brain, behavior, & immunity - health · 2025Article
- Fibromyalgia diagnosis from a multi-omics approach: a gut feeling.Frontiers in microbiology · 2025Article
- Why PNI scientists need to engage in exploratory hypothesis-generating biomarker studies.Brain, behavior, & immunity - health · 2024Article
- Identification of unique genomic signatures in patients with fibromyalgia and chronic pain.Scientific reports · 2024Article
- Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Advance in the mechanism and clinical research of myalgia in long COVID.American journal of clinical and experimental immunology · 2024Review
- A Manifesto in Defense of Pain Complexity: A Critical Review of Essential Insights in Pain Neuroscience.Journal of clinical medicine · 2023Review
- Links between brain neuroimaging and blood inflammatory markers in urological chronic pelvic pain syndrome.Physiology & behavior · 2023Article
- Multivariate analyses of immune markers reveal increases in plasma EN-RAGE in first-episode psychosis patients.Translational psychiatry · 2023Article
- Article
- Inflammatory Blood Signature Related to Common Psychological Comorbidity in Chronic Pain.Biomedicines · 2023Article
- The Vastus Lateralis Muscle Interstitium Proteome Changes after an Acute Nociception in Patients with Fibromyalgia Compared to Healthy Subjects-A Microdialysis Study.Biomedicines · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibromyalgia (FM) is a complex pain condition where the pathophysiological and molecular mechanisms are not fully elucidated. The primary aim of this study was to investigate the plasma proteome profile in women with FM compared to controls. The secondary aim was to investigate if plasma protein patterns correlate with the clinical variables pain intensity, sensitivity, and psychological distress. Clinical variables/background data were retrieved through questionnaires. Pressure pain thresholds (PPT) were assessed using an algometer. The plasma proteome profile of FM (n = 30) and controls (n = 32) was analyzed using two-dimensional gel electrophoresis and mass spectrometry. Quantified proteins were analyzed regarding group differences, and correlations to clinical parameters in FM, using multivariate statistics. Clear significant differences between FM and controls were found in proteins involved in inflammatory, metabolic, and immunity processes. Pain intensity, PPT, and psychological distress in FM had associations with specific plasma proteins involved in blood coagulation, metabolic, inflammation and immunity processes. This study further confirms that systemic differences in protein expression exist in women with FM compared to controls and that altered levels of specific plasma proteins are associated with different clinical parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.