ArticleScientific reports2020
Deciphering the coagulation profile through the dynamics of thrombin activity.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Mesoscale Simulations of Blood Coagulation in Flow and Quiescent Domains Using SDPD.International journal for numerical methods in biomedical engineering · 2026Article
- A miniaturized chemiluminescent thrombin generation assay to assess the effect of APCC in persons with hemophilia A with inhibitors: an observational study.Research and practice in thrombosis and haemostasis · 2026Observational
- Thrombin dynamics and clinical events in cirrhosis: low prothrombin conversion predicts bleeding risk.Frontiers in cell and developmental biology · 2026Article
- Prothrombin conversion accelerates with increasing age in women but not in men: findings from the Moli-sani Cohort Study.Research and practice in thrombosis and haemostasis · 2026Article
- The kinetics and interplay of thrombin inhibition by 4 plasma proteinase inhibitors.Blood vessels, thrombosis & hemostasis · 2025Article
- Clinical Outcomes and Inflammatory Response to the Enhanced Recovery After Surgery (ERAS) Protocol in Adolescent Idiopathic Scoliosis Surgery: An Observational Study.International journal of molecular sciences · 2025Observational
- Age- and sex-dependency of thrombin generation parameters in the general Italian population: the Moli-sani study.Frontiers in cardiovascular medicine · 2025Article
- Single-Particle Plasmon Sensor to Monitor Proteolytic Activity in Real Time.ACS applied optical materials · 2023Article
- Exosomal microRNAs from Mesenchymal Stem Cells: Novel Therapeutic Effect in Wound Healing.Tissue engineering and regenerative medicine · 2023Review
- Abacavir use is associated with increased prothrombin conversion.Frontiers in immunology · 2023Article
- Coagulation parameters predict COVID-19-related thrombosis in a neural network with a positive predictive value of 98.Frontiers in immunology · 2022Article
- Low antithrombin levels are associated with low risk of cardiovascular death but are a risk factor for cancer mortality.PloS one · 2022Article
- Population-wide persistent hemostatic changes after vaccination with ChAdOx1-S.Frontiers in cardiovascular medicine · 2022Article
- Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay.Frontiers in cardiovascular medicine · 2022Article
- Functional changes in hemostasis during asexual and sexual parasitemia in a controlled human malaria infection.PloS one · 2022Article
- Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process.Frontiers in cardiovascular medicine · 2022Article
- Tailoring the effect of antithrombin-targeting therapy in haemophilia A using in silico thrombin generation.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thrombosis has proven to be extremely difficult to predict. Measuring the generation of thrombin is a very sensitive method to detect changes in the hemostatic system. We developed a method based on the generation of thrombin to further fingerprint hemostasis, which we have named thrombin dynamics. Via this method we are able to exactly measure the prothrombin conversion and thrombin inactivation, and any change in the coagulation cascade will be reflected in these two processes. In the current study we analyzed the importance of the members of the prothrombin complex on the dynamics of thrombin activation and inactivation. We show that prothrombin conversion is predominantly influenced by factor X and antithrombin, which will provide essential insights in complex thrombosis-related diseases, such as liver cirrhosis and kidney failure.
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