ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Hippocampal Representation of Threat Features and Behavior in a Human Approach-Avoidance Conflict Anxiety Task.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- A neuroimaging meta-analysis on social impression formation of stable characteristics.Cerebral cortex (New York, N.Y. : 1991) · 2026Pooled it
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- Context-dependent feature modulation shapes human decision policies in approach-avoidance conflicts.PLoS computational biology · 2026Article
- Perceived Racism, Brain Development, and Internalizing and Externalizing Symptoms: Findings From the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- A novel approach-avoidance task to study decision making under outcome uncertainty.Psychonomic bulletin & review · 2026Article
- Cortical-limbic circuit dynamics of approach-avoidance conflict in humans.Nature communications · 2026Article
- Human approach-avoidance conflict behaviour relates to transdiagnostic psychiatric symptom dimensions.Translational psychiatry · 2026Article
- Examining motivational profiles in the dark personality tetrad using an approach-avoidance conflict task.PloS one · 2025Article
- How Distributed Subcortical Integration of Reward and Threat May Inform Subsequent Approach-Avoidance Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neurobiological foundations and clinical relevance of effort-based decision-making.Brain imaging and behavior · 2024Review
- Brain volumes, behavioral inhibition, and anxiety disorders in children: results from the adolescent brain cognitive development study.BMC psychiatry · 2024Article
- Reward processing deficits arise early in familial frontotemporal dementia.Frontiers in neuroscience · 2024Article
- Preclinical and clinical evidence on the approach-avoidance conflict evaluation as an integrative tool for psychopathology.Epidemiology and psychiatric sciences · 2022Article
- Measuring maladaptive avoidance: from animal models to clinical anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- The anxiety-specific hippocampus-prefrontal cortex pathways links to procrastination through self-control.Human brain mapping · 2022Article
- Cross-species anxiety tests in psychiatry: pitfalls and promises.Molecular psychiatry · 2022Review
- Anxiety and Alzheimer's disease: Behavioral analysis and neural basis in rodent models of Alzheimer's-related neuropathology.Neuroscience and biobehavioral reviews · 2021Review
- Mental Resilience and Coping With Stress: A Comprehensive, Multi-level Model of Cognitive Processing, Decision Making, and Behavior.Frontiers in behavioral neuroscience · 2021Article
- Hippocampal Representation of Threat Features and Behavior in a Human Approach-Avoidance Conflict Anxiety Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
Decisions under threat are crucial to survival and require integration of distinct situational features, such as threat probability and magnitude. Recent evidence from human lesion and neuroimaging studies implicated anterior hippocampus (aHC) and amygdala in approach-avoidance decisions under threat, and linked their integrity to cautious behavior. Here we sought to elucidate how threat dimensions and behavior are represented in these structures. Twenty human participants (11 female) completed an approach-avoidance conflict task during high-resolution fMRI. Participants could gather tokens under threat of capture by a virtual predator, which would lead to token loss. Threat probability (predator wake-up rate) and magnitude (amount of token loss) varied on each trial. To disentangle effects of threat features, and ensuing behavior, we performed a multifold parametric analysis. We found that high threat probability and magnitude related to BOLD signal in left aHC/entorhinal cortex. However, BOLD signal in this region was better explained by avoidance behavior than by these threat features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.