Evidence map›Paper›PMID 32719155›Full record

ArticleInfection and immunity2020

Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling through the Interleukin-1 Receptor.

Doris L LaRock, Raedeen Russell, Anders F Johnson, Shyra Wilde, Christopher N LaRock

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Cell wall remodeling-dependent morphotype switch inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Pentamidine inhibition of streptopain attenuatesbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Group AInfection and immunity · 2024
    Article
  11. Interplay between group AMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Gasdermins in sepsis.Frontiers in immunology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Doris L LaRockDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Raedeen RussellDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Anders F JohnsonMicrobiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, Georgia, USA.
Shyra WildeMicrobiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, Georgia, USA.
Christopher N LaRockDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA christopher.larock@emory.edu.ORCID 0000-0003-3035-5331
Emory University · US

Funding

IL-1 regulation of group A Streptococcus infectionK22AI130223 · NIAID · EMORY UNIVERSITY · PI LAROCK, CHRISTOPHER N · 2018 to 2019
$269k
NIAID NIH HHS K22 AI130223
6 · The paper itself

Abstract

Group A

Indexed as

AnimalsAnti-Bacterial AgentsBacterial ProteinsCaspase 1Chemotaxis, LeukocyteExotoxinsInflammationInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinMiceNasopharynxNeutrophilsPharyngitisReceptors, Interleukin-1 Type ISignal TransductionStreptococcal InfectionsAnti-Bacterial AgentsBacterial ProteinsCasp1 protein, mouseCaspase 1erythrogenic toxinExotoxinsIL1B protein, mouseIL1R1 protein, mouseInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinReceptors, Interleukin-1 Type Igroup A streptococcusinflammationneutrophilspathogenesisproteasesrespiratory pathogensStreptococcus pyogenesvirulence factors

Identifiers

PMID32719155
PMCPMC7504964
OpenAlexW3045857614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.