Evidence map›Paper›PMID 32719153›Full record

ArticleInfection and immunity2020

Leukocidins and the Nuclease Nuc Prevent Neutrophil-Mediated Killing of Staphylococcus aureus Biofilms.

Mohini Bhattacharya, Evelien T M Berends, Xuhui Zheng, Preston J Hill, Rita Chan, Victor J Torres, Daniel J Wozniak

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. The evolving landscape ofFrontiers in immunology · 2026
    Pooled it
  2. Article
  3. Engineered bacteria reprogram tumor microenvironmentActa pharmaceutica Sinica. B · 2026
    Article
  4. Review
  5. Article
  6. Methicillin-resistantiScience · 2026
    Review
  7. Review
  8. Article
  9. Biofilm-associated molecular patterns: BAMPs.Infection and immunity · 2025
    Review
  10. Review
  11. Regulatory Effect of PGEBiomolecules · 2025
    Article
  12. Article
  13. Article
  14. Pathogens (Basel, Switzerland) · 2025
    Review
  15. Article
  16. Bacterial and host interactions inFrontiers in microbiology · 2025
    Review
  17. Matrix porosity is associated withbioRxiv : the preprint server for biology · 2024
    Article
  18. Phenotypic Variation inAntibiotics (Basel, Switzerland) · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mohini BhattacharyaDepartment of Microbiology, Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-0268-6379
Evelien T M BerendsDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Xuhui ZhengDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Preston J HillDepartment of Microbial Infection and Immunity, Ohio State University, Columbus, Ohio, USA.
Rita ChanDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Victor J TorresDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Daniel J WozniakDepartment of Microbiology, Ohio State University, Columbus, Ohio, USA Daniel.Wozniak@osumc.edu.
New York University · USThe Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Mechanistic Studies Of The Staphylococcus aureus LukAB CytotoxinR01AI099394 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Victor J. Torres · 2013 to 2026
$6.1M
Contribution of LukED to Staphylococcus aureus pathobiologyR01AI105129 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI TORRES, VICTOR J. · 2014 to 2023
$4.9M
The biofilm matrix of P. aeruginosaR01AI143916 · NIAID · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL, PARSEK, MATTHEW R. · 2019 to 2023
$2.9M
Revisiting alginate paradigmsR01AI134895 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2018 to 2022
$2.5M
Biofilms and Immunity in Chronic WoundsR01NR013898 · NINR · OHIO STATE UNIVERSITY · PI SEN, CHANDAN K, WOZNIAK, DANIEL J · 2012 to 2016
$2.1M
NCI NIH HHS P30 CA016058NIAID NIH HHS R01 AI099394NIAID NIH HHS R01 AI105129NIAID NIH HHS R01 AI134895NIAID NIH HHS R01 AI143916NINR NIH HHS R01 NR013898
6 · The paper itself

Abstract

Bacterial biofilms are linked with chronic infections and have properties distinct from those of planktonic, single-celled bacteria. The virulence mechanisms associated with

Indexed as

BiofilmsImmune EvasionBacterial ProteinsExtracellular TrapsHumansLeukocidinsMicrobial ViabilityMicrococcal NucleaseNeutrophilsPhagocytosisStaphylococcus aureusVirulenceBacterial ProteinsLeukocidinsMicrococcal Nucleasenuc protein, staphylococcusbiofilmsNETsneutrophilphagocytosisS. aureus

Identifiers

PMID32719153
PMCPMC7504955
OpenAlexW3045270217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.