Evidence map›Paper›PMID 32719136›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Elevated energy requirement of cone photoreceptors.

Norianne T Ingram, Gordon L Fain, Alapakkam P Sampath

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 121 citations in OpenAlex.

  1. Impaired Rod-Mediated Vision is the Functional Hallmark of Ageing and Early and Intermediate Age-Related Macular Degeneration.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Review
  2. Article
  3. Retbindin Dynamically Redistributes to Preserve Retinal Flavin-Dependent Homeostasis in Response to Riboflavin Availability and Circadian Demand.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  11. High-altitude retinopathy with isolated ellipsoid zone loss: a case report.Documenta ophthalmologica. Advances in ophthalmology · 2026
    Article
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  18. iScience · 2025
    Article
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  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Norianne T IngramDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095-7239.
Gordon L FainDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095-7239.
Alapakkam P SampathDepartment of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095-7000 asampath@jsei.ucla.edu.ORCID 0000-0002-0785-9577
University of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, DAVID S WILLIAMS · 1985 to 2026
$16.8M
PHYSIOLOGY OF PHOTORECEPTORSR01EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORDON Lee FAIN · 1985 to 2026
$9.9M
Vision Science Training ProgramT32EY007026 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alapakkam P Sampath · 1985 to 2026
$5.7M
Molecular Mechanisms of Photoreceptor AdaptationR01EY029817 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAMPATH, ALAPAKKAM P · 2019 to 2023
$2.1M
MOLECULAR GENETICS OF EARLY EYE DEVELOPMENTZ01EY000311 · NEI · NATIONAL EYE INSTITUTE · PI TOMAREV, STANISLAV I · 1996 to 2008
$941k
Intramural NIH HHS Z01 EY000311NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY001844NEI NIH HHS R01 EY029817NEI NIH HHS T32 EY007026
6 · The paper itself

Abstract

We have used recent measurements of mammalian cone light responses and voltage-gated currents to calculate cone ATP utilization and compare it to that of rods. The largest expenditure of ATP results from ion transport, particularly from removal of Na

Indexed as

Adenosine TriphosphateAnimalsCalciumCyclic GMPCyclic Nucleotide-Gated Cation ChannelsFovea CentralisHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIon Channel GatingLightMicePresynaptic TerminalsRetinaRetinal Cone Photoreceptor CellsRetinal Rod Photoreceptor CellsSodiumAdenosine TriphosphateCalciumCyclic GMPCyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsSodiumdegenerationfoveametabolismphotoreceptorretina

Identifiers

PMID32719136
PMCPMC7431031
OpenAlexW3045207175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.