ArticleLife sciences in space research2020
Exercise and Testosterone Countermeasures to Mitigate Metabolic Changes during Bed Rest.
Article in Life sciences in space research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Bed rest decreases resting skeletal muscle OExperimental physiology · 2026Article
- The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis.Experimental physiology · 2026Article
- A systematic review of microgravity on reproductive systems: Implications for space biology and human health.iScience · 2026Review
- Adjuvant pharmacological strategies for the musculoskeletal system during long-term space missions.British journal of clinical pharmacology · 2026Review
- Myonuclear and satellite cell content of the vastus lateralis and soleus with 70 days of simulated microgravity and the NASA SPRINT exercise program.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- NASA SPRINT exercise program efficacy for vastus lateralis and soleus skeletal muscle health during 70 days of simulated microgravity.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Effects of exercise countermeasures on multisystem function in long duration spaceflight astronauts.NPJ microgravity · 2023Article
- Implementation of exercise countermeasures during spaceflight and microgravity analogue studies: Developing countermeasure protocols for bedrest in older adults (BROA).Frontiers in physiology · 2022Review
- Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing.Frontiers in bioengineering and biotechnology · 2022Review
- Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration.The Journal of physiology · 2021Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesExercise is a front-line countermeasure used to maintain astronaut health during long-duration spaceflight; however, reductions in metabolic health still occur. Accordingly, we evaluated serial changes in metabolic parameters in a spaceflight analog and evaluated the efficacy of exercise with or without the addition of low-dose testosterone treatment on mitigating adverse metabolic changes. SUBJECTS/
methodsHealthy young (<55 years) men were randomly assigned to one of three groups during 70-days of strict, diet controlled, 6° head-down bed rest: Control (CON, n=9), exercise plus testosterone countermeasure (TEX, n=8), or exercise countermeasure plus placebo (PEX, n=9). Basal metabolic rate (BMR), glucose tolerance, and insulin sensitivity were measured before, during, and after bed rest. Exercise energy expenditure and excess post-exercise oxygen consumption were measured in TEX and PEX subjects during bed rest.
resultsLeptin decreased during bed rest (Pre to BR+0 changed from 6.9 ± 5.1, 5.8 ± 4.2, and 4.7 ± 4.1 to 7.9 ±3.6, 6.5 ± 4.6, and 4.1 ±3.0 ug• L
conclusionThis study confirmed that inactivity during 70 days of head-down bed rest adversely affects metabolic health. The daily exercise countermeasures were beneficial but not completely protective of bed rest induced decrements in metabolic health. Supplementary countermeasures such as testosterone may provide additional benefits not provided by exercise alone.
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