Evidence map›Paper›PMID 32718355›Full record

SynthesisHealth and quality of life outcomes2020

Utility value estimates in cardiovascular disease and the effect of changing elicitation methods: a systematic literature review.

Marissa Blieden Betts, Pratik Rane, Evelien Bergrath, Madhura Chitnis, Mohit Kumar Bhutani, Claudia Gulea, Yi Qian, Guillermo Villa

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Health and quality of life outcomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  10. Cost-effectiveness of population screening for aortic stenosis.European heart journal. Quality of care & clinical outcomes · 2025
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  19. Cost-utility analysis of a supervised exercise intervention for women with early-stage endometrial cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Marissa Blieden BettsEvidence Synthesis, Modeling & Communication Evidera Inc, Waltham, MA, USA. Marissa.Betts@evidera.com.ORCID http://orcid.org/0000-0002-0557-3946
Pratik RaneAmgen Inc, Global Health Economics, Thousand Oaks, CA, USA.
Evelien BergrathEvidence Synthesis, Modeling & Communication Evidera Inc, Waltham, MA, USA.
Madhura ChitnisEvidence Synthesis, Modeling & Communication Evidera Inc, Waltham, MA, USA.
Mohit Kumar BhutaniBresMed Health Solutions Ltd., Gurugram, Haryana, India.
Claudia GuleaEvidence Synthesis, Modeling & Communication, Evidera, London, UK.
Yi QianAmgen Inc, Intercontinental HQ-Value, Access & Policy, Thousand Oaks, CA, USA.
Guillermo VillaAmgen (Europe) GmbH, Global Health Economics, Zug, Switzerland.
Amgen (United States) · USAmgen (Switzerland) · CHIthaka Harbors · US

Funding

Amgen Not Applicable
6 · The paper itself

Abstract

objectiveIdentify the most recent utility value estimates for cardiovascular disease (CVD) via systematic literature review (SLR) and explore trends in utility elicitation methods in the last 6 years.

methodsThis SLR was updated on January 25, 2018, and identified studies reporting utilities for myocardial infarction (MI), stroke, angina, peripheral artery disease (PAD), and any-cause revascularization by searching Embase, PubMed, Health Technology Assessment Database, and grey literature.

resultsA total of 375 studies reported CVD utilities (pre-2013 vs post-2013: MI, 38 vs 32; stroke, 86 vs 113; stable angina, 8 vs 9; undefined/unstable angina, 23 vs 8; PAD, 29 vs 13; revascularization, 54 vs 40). Median average utilities for MI, stroke, and revascularization increased over time (pre-2013 vs post-2013: MI, 0.71 vs 0.79; stroke, 0.63 vs 0.64; revascularization, 0.76 vs 0.81); angina and PAD showed a decrease in median values over time (stable angina, 0.83 vs 0.72; undefined/unstable angina, 0.70 vs 0.69; PAD, 0.76 vs 0.71). The proportion of utility estimates from trials increased across health states (pre-2013 vs post-2013: 22.5% vs 37.2%), as did the proportion of trials using the EuroQol Five Dimensions Questionnaire (EQ-5D; pre-2013 vs post-2013: 73.8% vs 91.4%). Use of methods such as the standard gamble, time trade-off, and Health Utilities Index has declined.

conclusionsHealth state utilities for cardiovascular health states have changed in the last 6 years, likely due to changes in the types of studies conducted, the patient populations evaluated, and possibly changing utility elicitation methods. The EQ-5D has been used more frequently.

Indexed as

Health Status IndicatorsQuality of LifeCardiovascular DiseasesCost-Benefit AnalysisFemaleHumansMaleMiddle AgedQuality-Adjusted Life YearsSurveys and QuestionnairesCardiovascular diseaseEQ-5DHealth state utilitiesTrends

Identifiers

PMID32718355
PMCPMC7385861
OpenAlexW3045728995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.