Evidence map›Paper›PMID 32718272›Full record

ArticleBioengineered2020

Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells.

Jingzhou Li, Qianyi Deng, Wenguo Fan, Qi Zeng, Hongwen He, Fang Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Exposure to Dim Light at Night Impairs Photoperiodic and Metabolic Gene Expression in Syrian Hamsters (Mesocricetus auratus).Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026
    Article
  3. Article
  4. Article
  5. Melatonin and the Dental Pulp: A Scoping Review.International endodontic journal · 2026
    Article
  6. Review
  7. Review
  8. Melatonin: A Potential Regulator of DNA Methylation.Antioxidants (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jingzhou LiDepartment of Pediatric Dentistry, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University , Guangzhou, China.ORCID 0000-0003-3153-9554
Qianyi DengPaediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong , Hong Kong, China.
Wenguo FanGuangdong Provincial Key Laboratory of Stomatology , Guangzhou, China.
Qi ZengDepartment of Pediatric Dentistry, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University , Guangzhou, China.
Hongwen HeGuangdong Provincial Key Laboratory of Stomatology , Guangzhou, China.
Fang HuangDepartment of Pediatric Dentistry, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University , Guangzhou, China.ORCID 0000-0003-3408-8090
Sun Yat-sen University · CNUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differentiation potency of human dental pulp cells (hDPCs) is essential for dentin regeneration. DNA methylation is one of the major epigenetic mechanisms and is suggested to involve in differentiation of hDPCs, the machinery of which includes DNA methyltransferase enzymes (DNMTs) and methyl-CpG-binding domain proteins (MBDs). Our previous study has found that melatonin (MT) promoted hDPC differentiation, but its mechanism remains elusive. We aimed to investigate the role of DNA methylation in the promotion of MT to differentiation of hDPCs

Indexed as

AdolescentAdultBlotting, WesternCell DifferentiationCell ProliferationCells, CulturedCell SurvivalDental PulpDNA-Binding ProteinsDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3ADNA Methyltransferase 3BFemaleFluorescent Antibody TechniqueDNA-Binding ProteinsDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BDNMT1 protein, humanDNMT3A protein, humanMBD1 protein, humanMBD2 protein, humanMBD3 protein, humanMBD5 protein, humanMBD6 protein, humanMECP2 protein, humanMelatoninMethyl-CpG-Binding Protein 2Transcription FactorsDNA methylationDNMT1global methylationHuman dental pulp cellsMeCP2melatoninodontogenic differentiation

Identifiers

PMID32718272
PMCPMC8291816
OpenAlexW3046002619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.