ArticleInternational journal of molecular sciences2020
Tomatine Displays Antitumor Potential in In Vitro Models of Metastatic Melanoma.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Enhanced Inhibition of HNSCC Growth by α-Tomatine and Cisplatin via MAPK-Mediated Apoptosis.Molecules (Basel, Switzerland) · 2026Article
- Glycoalkaloids Affect the Animal Nervous System: A Review.Journal of toxicology · 2026Review
- Anti-inflammatory activity of α-tomatineInternational journal of medical sciences · 2026Article
- Bioactive compounds in the modulation of oxidative stress in monocytes and macrophages.Scientific reports · 2025Article
- Main chemical constituents and mechanism of anti-tumor action of Solanum nigrum L.Cancer medicine · 2024Review
- Agri-Food Waste Recycling for Healthy Remedies: Biomedical Potential of Nutraceuticals from Unripe Tomatoes (Foods (Basel, Switzerland) · 2024Review
- Circulating extracellular vesicles are monitoring biomarkers of anti-PD1 response and enhancer of tumor progression and immunosuppression in metastatic melanoma.Journal of experimental & clinical cancer research : CR · 2023Article
- Isomers of the Tomato Glycoalkaloids α-Tomatine and Dehydrotomatine: Relationship to Health Benefits.Molecules (Basel, Switzerland) · 2023Article
- Bioactive Compounds and Their Impact on Protein Modification in Human Cells.International journal of molecular sciences · 2022Article
- Sustainable Valorization of Tomato By-Products to Obtain Bioactive Compounds: Their Potential in Inflammation and Cancer Management.Molecules (Basel, Switzerland) · 2022Review
- Anticancer activity of glycoalkaloids fromFrontiers in pharmacology · 2022Review
- Biomaterial-Assisted Regenerative Medicine.International journal of molecular sciences · 2021Review
- Combined Experimental and Multivariate Model Approaches for Glycoalkaloid Quantification in Tomatoes.Molecules (Basel, Switzerland) · 2021Article
- Article
- Chemical Characterisation and Antihypertensive Effects of Locular Gel and Serum ofMolecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
There is a growing interest in the cytotoxic effects of bioactive glycoalkaloids, such as α-tomatine on tumor cells. Here, for the first time, we determine the antitumor potential of tomatine, a mixture of α-tomatine and dehydrotomatine, in metastatic melanoma (MM) cell lines harboring different BRAF and MC1R variants. We performed cytotoxicity experiments and annexin-V/propidium iodide staining to assess the apoptotic/necrotic status of the cells. ER stress and autophagy markers were revealed by Western Blot, whereas antiangiogenic and vascular-disrupting effects were evaluated through a capillary tube formation assay on matrigel and by ELISA kit for VEGF release determination. Cell invasion was determined by a Boyden chamber matrigel assay. Tomatine reduced 50% of cell viability and induced a concentration-dependent increase of apoptotic cells in the range of 0.5-1 μM in terms of α-tomatine. The extent of apoptosis was more than two-fold higher in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.