Evidence map›Paper›PMID 32718057›Full record

ArticleInternational journal of molecular sciences2020

PD-L1 Expression and a High Tumor Infiltrate of CD8+ Lymphocytes Predict Outcome in Patients with Oropharyngeal Squamous Cells Carcinoma.

Nora Wuerdemann, Sibel E Gültekin, Katharina Pütz, Claus Wittekindt, Christian U Huebbers, Shachi J Sharma, Hans Eckel, Anna B Schubotz, Stefan Gattenlöhner, Reinhard Büttner and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Redefining oropharyngeal cancer in the HPV era: integrating precision medicine and immunotherapeutic frontiers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  6. The membrane-associated ubiquitin ligase MARCHF8 degrades MHC-I in HPV-positive head and neck cancer for immune evasion.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Nora WuerdemannDepartment of Otorhinolaryngology, Head and Neck Surgery, Klinikstrasse 33, University of Giessen, 35392 Giessen, Germany.
Sibel E GültekinDepartment of Oral Pathology, Faculty of Dentistry, Biskek Caddesi, Emek, University of Gazi, 06510 Ankara, Turkey.
Katharina PützInstitute of Pathology, Kerpener Strasse 62, University of Cologne, 50937 Cologne, Germany.
Claus WittekindtDepartment of Otorhinolaryngology, Head and Neck Surgery, Klinikstrasse 33, University of Giessen, 35392 Giessen, Germany.
Christian U HuebbersDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany.
Shachi J SharmaDepartment of Otorhinolaryngology, Head and Neck Surgery, Klinikstrasse 33, University of Giessen, 35392 Giessen, Germany.
Hans EckelDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany.
Anna B SchubotzDepartment of Otorhinolaryngology, Head and Neck Surgery, Klinikstrasse 33, University of Giessen, 35392 Giessen, Germany.
Stefan GattenlöhnerInstitute of Pathology, Langhansstrasse 10, University of Giessen, 35392 Giessen, Germany.
Reinhard BüttnerInstitute of Pathology, Kerpener Strasse 62, University of Cologne, 50937 Cologne, Germany.
Ernst-Jan SpeelDepartment of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, USA Maastrichtthe, The Netherlands.
Jens P KlussmannDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany.
Steffen WagnerDepartment of Otorhinolaryngology, Head and Neck Surgery, Klinikstrasse 33, University of Giessen, 35392 Giessen, Germany.
Alexander QuaasInstitute of Pathology, Kerpener Strasse 62, University of Cologne, 50937 Cologne, Germany.
University of Cologne · DEJustus-Liebig-Universität Gießen · DEGazi University · TRMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carcinogenesis of human papillomavirus (HPV)-related (+) oropharyngeal squamous cell carcinoma (OPSCC) differs from HPV-negative (-) OPSCC. HPV-related immune-escape-mechanism could be responsible for the development and progression of HPV+ tumors and an immunophenotype different from HPV- OPSCC is expected. The purpose of this study was to analyze the expression of programmed cell death protein 1 ligand 1 (PD-L1) and its prognostic relevance in relation to CD8+ tumor infiltrating lymphocytes (TILs) and the major histocompatibility complex (MHC) I expression in OPSCC. We quantified PD-L1 expression on tumor cells (TC) and macrophages and MHC I expression in association to CD8

Indexed as

CD8-Positive T-LymphocytesHead and Neck NeoplasmsLymphocytes, Tumor-InfiltratingSquamous Cell Carcinoma of Head and NeckAdultAgedAged, 80 and overB7-H1 AntigenBiomarkers, TumorDisease-Free SurvivalFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm ProteinsB7-H1 AntigenBiomarkers, TumorCD274 protein, humanNeoplasm ProteinsCD8-positive T-lymphocyteshuman papillomavirusmacrophagesMHC Ioropharyngeal squamous cell carcinomaprognosisprogrammed cell death 1 ligand 1tumor micro-environment

Identifiers

PMID32718057
PMCPMC7432501
OpenAlexW3044277860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.