ReviewNutrients2020
Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Experimental Evidence of Caffeic Acid's Neuroprotective Activity in Alzheimer's Disease: In Vitro, In Vivo, and Delivery-Based Insights.Medicina (Kaunas, Lithuania) · 2025Pooled it
- A Systematic Review and Comprehensive Evaluation of Human Intervention Studies to Unravel the Bioavailability of Hydroxycinnamic Acids.Antioxidants & redox signaling · 2024Pooled it
- Synthesis and Biological Activity Assessment of Caffeic Acid Azaheterocyclic Amide Derivatives.International journal of molecular sciences · 2026Article
- Cardioprotective Potential of Grape-Derived Polyphenols in Cancer Therapy-Related Cardiotoxicity.International journal of molecular sciences · 2026Review
- TransfersomILs: A Synergy to Boost the Skin Delivery of Hydroxycinnamic Acids.Pharmaceutics · 2026Article
- Phenolic Profiling of Some Bryophyte Species: In Vitro and In Silico Assessment of Their Antimicrobial Potentials.Molecules (Basel, Switzerland) · 2026Article
- Polyphenols in food and food wastes: Extraction, isolation, and health applications.Food chemistry. Molecular sciences · 2026Review
- Review
- Chemical Composition and Biological Activity of Phenolic Compounds and Carotenoids Extracted from Yellow-Purple Polignano Carrots.Foods (Basel, Switzerland) · 2026Article
- Non-solvent cinnamic acid-based gel patch for transdermal drug delivery.Journal of advanced research · 2026Article
- Investigation of the Antioxidant Activity of Hydroxycinnamic Acids, Hydroxybenzoic Acids, and Their Synthetic Diazomethane Derivatives.Molecules (Basel, Switzerland) · 2026Article
- Targeting hypertension through natural phenolics: The multifaceted role of cinnamic acid and its derivatives.Pflugers Archiv : European journal of physiology · 2026Review
- Article
- Decoding Cretan Wines: Phenolic Profiling of Greek Indigenous Wine Varieties Using LC-QTOF-MS.Molecules (Basel, Switzerland) · 2026Article
- The diet-derived gut microbial metabolite 3-phenylpropionic acid reverses insulin resistance and obesity-associated metabolic dysfunction.Molecular metabolism · 2025Article
- Hydrothermal and Organosolv Treatments for Hydroxycinnamate Release from Corn Stover: StrongMolecules (Basel, Switzerland) · 2025Article
- The Biologically Active Compounds in Fruits of Cultivated Varieties and Wild Species of Apples.Molecules (Basel, Switzerland) · 2025Review
- Review
- Phytochemical Profiling, Antioxidant Activity, and In Vitro Cytotoxic Potential of MangrovePharmaceuticals (Basel, Switzerland) · 2025Article
- Unlocking Polyphenol Efficacy: The Role of Gut Microbiota in Modulating Bioavailability and Health Effects.Nutrients · 2025Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydroxycinnamic acids (HCAs) are important natural phenolic compounds present in high concentrations in fruits, vegetables, cereals, coffee, tea and wine. Many health beneficial effects have been acknowledged in food products rich in HCAs; however, food processing, dietary intake, bioaccessibility and pharmacokinetics have a high impact on HCAs to reach the target tissue in order to exert their biological activities. In particular, metabolism is of high importance since HCAs' metabolites could either lose the activity or be even more potent compared to the parent compounds. In this review, natural sources and pharmacokinetic properties of HCAs and their esters are presented and discussed. The main focus is on their metabolism along with biological activities and health benefits. Special emphasis is given on specific effects of HCAs' metabolites in comparison with their parent compounds.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.