ArticlePharmaceutics2020
Antimicrobial Activities of Highly Bioavailable Organic Salts and Ionic Liquids from Fluoroquinolones.
Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Ciprofloxacin-Based Ionic Liquids Increase Mutation Frequency inAntibiotics (Basel, Switzerland) · 2026Article
- Review
- Synthesis, characterization, antimicrobial activity andRSC advances · 2025Article
- Effects of organic salts of virucidal and antiviral compounds from Nelumbo nucifera and Kaempferia parviflora against SARS-CoV-2.Scientific reports · 2025Article
- Synthesis, Characterization, Bioavailability and Antimicrobial Studies of Cefuroxime-Based Organic Salts and Ionic Liquids.Pharmaceutics · 2024Article
- Fluoroquinolone-Based Organic Salts (GUMBOS) with Antibacterial Potential.International journal of molecular sciences · 2023Article
- In Vitro Antimicrobial Studies of Mesoporous Silica Nanoparticles Comprising Anionic Ciprofloxacin Ionic Liquids and Organic Salts.Pharmaceutics · 2023Article
- Effect of new methionine-based ionic liquid on theIranian journal of microbiology · 2023Article
- Ionic Liquid-Based Polymer Nanocomposites for Sensors, Energy, Biomedicine, and Environmental Applications: Roadmap to the Future.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Novel Organic Salts Based on Mefloquine: Synthesis, Solubility, Permeability, and In Vitro Activity againstMolecules (Basel, Switzerland) · 2022Article
- Enhanced In Vitro Antiviral Activity of Hydroxychloroquine Ionic Liquids against SARS-CoV-2.Pharmaceutics · 2022Article
- Validation of Structural Grounds for Anomalous Molecular Mobility in Ionic Liquid Glasses.Molecules (Basel, Switzerland) · 2021Article
- Influence of the Use of an Ionic Liquid as Pre-Hydrodistillation Maceration Medium on the Composition and Yield ofMolecules (Basel, Switzerland) · 2021Article
- Ionic Liquid-Based Materials for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Docusate-Based Ionic Liquids of Anthelmintic Benzimidazoles Show Improved Pharmaceutical Processability, Lipid Solubility, andACS infectious diseases · 2021Article
- Recent Advances in Ionic Liquids in Biomedicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles.Pharmaceutics · 2021Article
- Facile and Rapid Isolation of Oxypeucedanin Hydrate and Byakangelicin fromMolecules (Basel, Switzerland) · 2021Article
- Ionic Liquids and Deep Eutectic Solvents for Application in Pharmaceutics.Pharmaceutics · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the development of novel antibiotics has been at a halt for several decades, chemically enhancing existing drugs is a very promising approach to drug development. Herein, we report the preparation of twelve organic salts and ionic liquids (OSILs) from ciprofloxacin and norfloxacin as anions with enhanced antimicrobial activity. Each one of the fluoroquinolones (FQs) was combined with six different organic hydroxide cations in 93-100% yield through a buffer-assisted neutralization methodology. Six of those were isomorphous salts while the remaining six were ionic liquids, with four of them being room temperature ionic liquids. The prepared compounds were not toxic to healthy cell lines and displayed between 47- and 1416-fold more solubility in water at 25 and 37 °C than the original drugs, with the exception of the ones containing the cetylpyridinium cation. In general, the antimicrobial activity against
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.