Evidence map›Paper›PMID 32717786›Full record

ArticleViruses2020

Comparison of Multiplexed Immunofluorescence Imaging to Chromogenic Immunohistochemistry of Skin Biomarkers in Response to Monkeypox Virus Infection.

Anup Sood, Yunxia Sui, Elizabeth McDonough, Alberto Santamaría-Pang, Yousef Al-Kofahi, Zhengyu Pang, Peter B Jahrling, Jens H Kuhn, Fiona Ginty

Open access · goldAbstract readComparative Study
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Machine Learning in Nonhuman Primate Models of Infectious Diseases: Current Applications and Future Perspectives.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Whole-Slide Imaging, Mutual Information Registration for Multiplex Immunohistochemistry and Immunofluorescence.Laboratory investigation; a journal of technical methods and pathology · 2023
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Topological-Preserving Membrane Skeleton Segmentation in Multiplex Immunofluorescence Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2023
    Article
  18. Article
  19. Monkeypox: An emerging zoonotic pathogen.World journal of virology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Anup SoodGE Research, 1 Research Circle, Niskayuna, NY 12309, USA.
Yunxia SuiGE Research, 1 Research Circle, Niskayuna, NY 12309, USA.
Elizabeth McDonoughGE Research, 1 Research Circle, Niskayuna, NY 12309, USA.
Alberto Santamaría-PangGE Research, 1 Research Circle, Niskayuna, NY 12309, USA.
Yousef Al-KofahiGE Research, 1 Research Circle, Niskayuna, NY 12309, USA.
Zhengyu PangGE Research, 1 Research Circle, Niskayuna, NY 12309, USA.
Peter B JahrlingIntegrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, B-8200 Research Plaza, Frederick, MD 21702, USA.
Jens H KuhnIntegrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, B-8200 Research Plaza, Frederick, MD 21702, USA.ORCID 0000-0002-7800-6045
Fiona GintyGE Research, 1 Research Circle, Niskayuna, NY 12309, USA.ORCID 0000-0001-6638-683X
GE Global Research (United States) · USNational Institutes of Health · US

Funding

NIAID NIH HHS HHSN272200700016INIAID NIH HHS HHSN272201800013C
6 · The paper itself

Abstract

Over the last 15 years, advances in immunofluorescence-imaging based cycling methods, antibody conjugation methods, and automated image processing have facilitated the development of a high-resolution, multiplexed tissue immunofluorescence (MxIF) method with single cell-level quantitation termed Cell DIVE

Indexed as

AnimalsBiomarkersChromogenic CompoundsFemaleFluorescent Antibody TechniqueImage Processing, Computer-AssistedImmunohistochemistryMacaca mulattaMaleMonkeypox virusMpox, MonkeypoxRetrospective StudiesSingle-Cell AnalysisSkinStaining and LabelingBiomarkersChromogenic CompoundsIHCimmunohistochemistrymonkeypoxmonkeypox virusMPXVmultiplexed immunofluorescenceMxIFOrthopoxvirusPoxviridaepoxvirus

Identifiers

PMID32717786
PMCPMC7472296
OpenAlexW3044434603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.