Evidence map›Paper›PMID 32717346›Full record

ArticleVirus research2020

Identification of high-affinity inhibitors of SARS-CoV-2 main protease: Towards the development of effective COVID-19 therapy.

Taj Mohammad, Anas Shamsi, Saleha Anwar, Mohd Umair, Afzal Hussain, Md Tabish Rehman, Mohamed F AlAjmi, Asimul Islam, Md Imtaiyaz Hassan

Open access · bronzeAbstract read
In one paragraph

Article in Virus research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 99 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Taj MohammadCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Anas ShamsiCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Saleha AnwarCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Mohd UmairDepartment of Computer Science, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Afzal HussainDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Md Tabish RehmanDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Mohamed F AlAjmiDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Asimul IslamCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Md Imtaiyaz HassanCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India. Electronic address: mihassan@jmi.ac.in.
Jamia Millia Islamia · INKing Saud University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease, caused by a newly emerged highly pathogenic virus called novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Targeting the main protease (M

Indexed as

AminoglycosidesAntiviral AgentsBetacoronavirusCatalytic DomainCoronavirus 3C ProteasesCoronavirus InfectionsCOVID-19Cysteine EndopeptidasesDrug DiscoveryGene ExpressionHumansLactamsLeucineMolecular Docking SimulationMolecular Dynamics SimulationPandemicsAminoglycosidesAntiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesGC376LactamsLeucineProtease InhibitorsPyrrolidinesSulfonic AcidsViral Nonstructural ProteinsCoronavirus disease 2019Drug discoveryMain proteaseMolecular dynamics simulationsSARS-CoV-2Virtual screening

Identifiers

PMID32717346
PMCPMC7380256
OpenAlexW3045130610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.